Research Article
Improved Stability of a Model IgG3 by DoE-Based Evaluation of Buffer Formulations
Table 3
0 analytic readout ranges for all DoEs for each buffer system; the range of values for A410, A280, and percent aggregates is given.This overview of the range of values gives a snapshot of how the different buffer systems compare to each other. Gross precipitation of larger aggregates that would have been centrifuged out of solution before SEC or trapped by the column frit may have led to an artifactual 0% aggregate reading for antibody in the histidine formulations.
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