Research Article
Uncovering Driver DNA Methylation Events in Nonsmoking Early Stage Lung Adenocarcinoma
Table 2
Functional annotation of driver-responsive network to KEGG signaling pathways (
value < 0.01).
| | Gene symbol | Enriched KEGG signaling pathway | value |
| | SPARCL1 | CYTOSOLIC_DNA_SENSING | |
| | TRPC6 | PPAR_SIGNALING | | | P53_SIGNALING | | | MTOR_SIGNALING | | | NOTCH_SIGNALING | |
| | EFEMP2 | NOTCH_SIGNALING | |
| | MX2 | RIG_I_LIKE_RECEPTOR_SIGNALING | |
| | PLA2G4C | PPAR_SIGNALING | | | P53_SIGNALING | | | MTOR_SIGNALING | | | NOTCH_SIGNALING | |
| | ST6GALNAC5 | PPAR_SIGNALING | | | P53_SIGNALING | | | MTOR_SIGNALING | | | NOTCH_SIGNALING | |
| | PLAT | TOLL_LIKE_RECEPTOR_SIGNALING | | | NOD_LIKE_RECEPTOR_SIGNALING | | | CYTOSOLIC_DNA_SENSING | | | JAK_STAT_SIGNALING | |
| | TCF21 | FC_EPSILON_RI_SIGNALING | |
| | GCNT3 | NOTCH_SIGNALING | |
| | MSR1 | NOTCH_SIGNALING | |
| | PTPRH | B_CELL_RECEPTOR_SIGNALING | |
| | HKDC1 | PPAR_SIGNALING | | | P53_SIGNALING | | | MTOR_SIGNALING | | | NOTCH_SIGNALING | |
| | CDH13 | ERBB_SIGNALING | | | T_CELL_RECEPTOR_SIGNALING | |
| | CFI | PPAR_SIGNALING | | | MAPK_SIGNALING | |
| | ARL14 | VEGF_SIGNALING | |
| | S100P | HEDGEHOG_SIGNALING | | | TGF_BETA_SIGNALING | |
| | DOCK2 | CHEMOKINE_SIGNALING | | | TOLL_LIKE_RECEPTOR_SIGNALING | | | NOD_LIKE_RECEPTOR_SIGNALING | | | T_CELL_RECEPTOR_SIGNALING | | | B_CELL_RECEPTOR_SIGNALING | |
| | TNFRSF1B | NOTCH_SIGNALING | | | FC_EPSILON_RI_SIGNALING | |
|
|
