Syntaxin 5 Overexpression and β-Amyloid 1–42 Accumulation in Endoplasmic Reticulum of Hippocampal Cells in Rat Brain Induced by Ozone Exposure

<div>Immunodetection of Syx5 and βA42 in the ER. Five micrometer-thick brain tissue sections form hippocampi of the control group (CTRL) and the rats exposed to O3 (0.25 ppm) for 3 months (3 M) are shown. Rabbit anti-βA42 is shown in red and Syntaxin 5 in green. DAPI staining (DAPI) and merge between red, green, and blue channels are shown (MERGE). The arrows indicate the overexpression of Syx5 and the intracellular βA42 deposition and colocalization in the ER (a). There was no βA42 detection at 7, 15, 30, and 60 days of treatment (data not shown). (b) Immunohistochemistry for Syx5 in brain slides of control (C), 15, 30, 60, and 90 days of treatment showing the overexpression of Syx5 under O3 treatment.</div>

BioMed Research International

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Figure 3: Syntaxin 5 Overexpression and β-Amyloid 1–42 Accumulation in Endoplasmic Reticulum of Hippocampal Cells in Rat Brain Induced by Ozone Exposure

Figure 3 | Syntaxin 5 Overexpression and β-Amyloid 1–42 Accumulation in Endoplasmic Reticulum of Hippocampal Cells in Rat Brain Induced by Ozone Exposure 