MicroRNAs in Coronary Heart Disease: Ready to Enter the Clinical Arena?

Table 2

Items reviewed on observational studies assessing the value of microRNAs as potential biomarkers for coronary artery disease and acute coronary syndrome. Table adapted by authors from [55].

Item	Issue	Question
(1)	Model assumption and goodness-of-fit	How far away from the data is the selected model?
(2)	Interaction analysis	Is there any potential variable that can modify the estimated effect?
(3)	Sensitivity analysis	Are the findings sufficiently robust, considering the process used to obtain them?
(4)	Crude and adjusted effect estimate	How much does the studied effect change when other variables are taken into account?
(5)	More than one adjusted model specified	Does the estimated effect differ between the different adjusted models, settings, specifications, and so forth?