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BioMed Research International
Volume 2016, Article ID 2173275, 6 pages
http://dx.doi.org/10.1155/2016/2173275
Research Article

Effects of Ginger Phenylpropanoids and Quercetin on Nrf2-ARE Pathway in Human BJ Fibroblasts and HaCaT Keratinocytes

1Institute of Molecular and Translational Medicine, Faculty of Medicine, Palacký University, Olomouc, Czech Republic
2Department of Organic Chemistry, Faculty of Science, Palacký University, Olomouc, Czech Republic

Received 28 October 2015; Accepted 29 December 2015

Academic Editor: Paul J. Higgins

Copyright © 2016 Ermin Schadich et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. K. Armstrong and A. Kricker, “The epidemiology of UV induced skin cancer,” Journal of Photochemistry and Photobiology B: Biology, vol. 63, no. 1–3, pp. 8–18, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. J. D'Orazio, S. Jarrett, A. Amaro-Ortiz, and T. Scott, “UV radiation and the skin,” International Journal of Molecular Sciences, vol. 14, no. 6, pp. 12222–12248, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. T. H. Rushmore and A.-N. T. Kong, “Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes,” Current Drug Metabolism, vol. 3, no. 5, pp. 481–490, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. F. Oesch, E. Fabian, K. Guth, and R. Landsiedel, “Xenobiotic-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models,” Archives of Toxicology, vol. 88, no. 12, pp. 2135–2190, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. T. A. Beyer, U. Auf dem Keller, S. Braun, M. Schäfer, and S. Werner, “Roles and mechanisms of action of the Nrf2 transcription factor in skin morphogenesis, wound repair and skin cancer,” Cell Death and Differentiation, vol. 14, no. 7, pp. 1250–1254, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. E. V. Knatko, S. H. Ibbotson, Y. Zhang et al., “Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans,” Cancer Prevention Research, vol. 8, no. 6, pp. 475–486, 2015. View at Publisher · View at Google Scholar
  7. T. Nguyen, P. Nioi, and C. B. Pickett, “The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress,” The Journal of Biological Chemistry, vol. 284, no. 20, pp. 13291–13295, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Magesh, Y. Chen, and L. Hu, “Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents,” Medicinal Research Reviews, vol. 32, no. 4, pp. 687–726, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. Y.-J. Surh, J. K. Kundu, and H.-K. Na, “Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals,” Planta Medica, vol. 74, no. 13, pp. 1526–1539, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Giudice, C. Arra, and M. C. Turco, “Review of molecular mechanisms involved in the activation of the Nrf2-ARE signaling pathway by chemopreventive agents,” Methods in Molecular Biology, vol. 647, pp. 37–74, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. K.-S. Chun, J. Kundu, J. K. Kundu, and Y.-J. Surh, “Targeting Nrf2-Keap1 signaling for chemoprevention of skin carcinogenesis with bioactive phytochemicals,” Toxicology Letters, vol. 229, no. 1, pp. 73–84, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Dugasani, M. R. Pichika, V. D. Nadarajah, M. K. Balijepalli, S. Tandra, and J. N. Korlakunta, “Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol,” Journal of Ethnopharmacology, vol. 127, no. 2, pp. 515–520, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. N. E. Fusenig and P. Boukamp, “Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes,” Molecular Carcinogenesis, vol. 23, no. 3, pp. 144–158, 1998. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Jiang, B. N. Timmermann, and D. R. Gang, “Characterization and identification of diarylheptanoids in ginger (Zingiber officinale Rosc.) using high-performance liquid chromatography/electrospray ionization mass spectrometry,” Rapid Communications in Mass Spectrometry, vol. 21, no. 4, pp. 509–518, 2007. View at Google Scholar · View at Scopus
  15. M. E. Swartz and B. Murphy, “New frontiers in chromatography,” American Laboratory, vol. 37, no. 3, pp. 22–27, 2005. View at Google Scholar · View at Scopus
  16. S. D. Jolad, R. C. Lantz, G. J. Chen, R. B. Bates, and B. N. Timmermann, “Commercially processed dry ginger (Zingiber officinale): composition and effects on LPS-stimulated PGE2 production,” Phytochemistry, vol. 66, no. 13, pp. 1614–1635, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. M.-J. Bak, S. Ok, M. Jun, and W.-S. Jeong, “6-Shogaol-rich extract from ginger up-regulates the antioxidant defense systems in cells and mice,” Molecules, vol. 17, no. 7, pp. 8037–8055, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Yamazaki, K. Egawa, K. Nose, S. Kunimoto, and T. Takeuchi, “HIF-1-dependent VEGF reporter gene assay by a stable transformant of CHO cells,” Biological and Pharmaceutical Bulletin, vol. 26, no. 4, pp. 417–420, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Hrabakova, M. Kollareddy, J. Tyleckova et al., “Cancer cell resistance to aurora kinase inhibitors: identification of novel targets for cancer therapy,” Journal of Proteome Research, vol. 12, no. 1, pp. 455–469, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. J. K. Kundu, H.-K. Na, and Y.-J. Surh, “Ginger-derived phenolic substances with cancer preventive and therapeutic potential,” Forum of Nutrition, vol. 61, pp. 182–192, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Yin, W. Li, Y.-O. Son et al., “Quercitrin protects skin from UVB-induced oxidative damage,” Toxicology and Applied Pharmacology, vol. 269, no. 2, pp. 89–99, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. J.-K. Kim, K.-M. Na, Y.-J. Surh, Y. Kim, and T.-Y. Kim, “[6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo,” Free Radical Research, vol. 41, no. 5, pp. 603–614, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. Zhang, V. Gonzalez, and M. J. Xu, “Expression and regulation of glutathione S-transferase P1-1 in cultured human epidermal cells,” Journal of Dermatological Science, vol. 30, no. 3, pp. 205–214, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. C. J. Henderson, A. W. McLaren, and C. R. Wolf, “In vivo regulation of human glutathione transferase GSTP by chemopreventive agents,” Cancer Research, vol. 74, no. 16, pp. 4378–4387, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. R. E. J. Howells, K. K. Dhar, P. R. Hoban et al., “Association between glutathione-S-transferase GSTP1 genotypes, GSTP1 over-expression, and outcome in epithelial ovarian cancer,” International Journal of Gynecological Cancer, vol. 14, no. 2, pp. 242–250, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. U. Tidefelt, A. Elmhorn-Rosenborg, C. Paul, X.-Y. Hao, B. Mannervik, and L. C. Eriksson, “Expression of glutathione transferase π as a predictor for treatment results at different stages of acute nonlymphoblastic leukemia,” Cancer Research, vol. 52, no. 12, pp. 3281–3285, 1992. View at Google Scholar · View at Scopus
  27. Y. Yamamoto, H. Konishi, D. Ichikawa et al., “Significance of GSTP1 for predicting the prognosis and chemotherapeutic efficacy in esophageal squamous cell carcinoma,” Oncology Reports, vol. 30, no. 4, pp. 1687–1694, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. Eralp, S. Keskin, E. Akışık et al., “Predictive role of midtreatment changes in survivin, GSTP1, and topoisomerase 2α expressions for pathologic complete response to neoadjuvant chemotherapy in patients with locally advanced breast cancer,” American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 36, no. 3, pp. 215–223, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. V. Adler, Z. Yin, S. Y. Fuchs et al., “Regulation of JNK signaling by GSTp,” The EMBO Journal, vol. 18, no. 5, pp. 1321–1334, 1999. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Karin and E. Gallagher, “From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance,” IUBMB Life, vol. 57, no. 4-5, pp. 283–295, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. Y. Wu, Y. Fan, B. Xue et al., “Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals,” Oncogene, vol. 25, no. 42, pp. 5787–5800, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. E. Laborde, “Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death,” Cell Death and Differentiation, vol. 17, no. 9, pp. 1373–1380, 2010. View at Publisher · View at Google Scholar · View at Scopus