The Role of Targeted Temperature Management in Adult Patients Resuscitated from Nonshockable Cardiac Arrests: An Updated Systematic Review and Meta-Analysis

Table 1

Characteristics of included studies in the meta-analysis.

Author (year)	Study design	Country	Setting	Arrest location	Cooling methods	Nonshockable		Length of follow-up
						Total	Cooled
Hachimi-Idrissi et al. (2005) [26]	RCT	Belgium	Single hospital	OHCA	External	33	16	6 months
Laurent et al. (2005) [27]	RCT	France	Single hospital	OHCA	Mixed	11	6	6 months
Holzer et al. (2006) [28]	OCS	Austria	Single hospital	Mixed	Internal	534	28	30 days
Oddo et al. (2006) [29]	OCS	Switzerland	Single hospital	OHCA	External	23	12	Discharge
Arrich et al. (2007) [30]	OCS	Europe	Multicenter	Mixed	Mixed	197	124	Discharge
Sunde et al. (2007) [31]	OCS	Norway	Single hospital	OHCA	Mixed	15	6	Discharge
Heer (2007) [32]	OCS	Germany	Single hospital	OHCA	Internal	18	10	Discharge
Rittenberger et al. (2008) [33]	OCS	USA	Single hospital	Mixed	Mixed	81	42	Discharge
Storm et al. (2008) [34]	OCS	Germany	Single hospital	OHCA	Mixed	49	18	Discharge
Bro-Jeppesen et al. (2009) [35]	OCS	Denmark	EMS + single hospital	OHCA	Mixed	34	13	Discharge/6 months
Gaieski et al. (2009) [36]	OCS	USA	Single hospital	OHCA	Mixed	18	9	Discharge
Whitfield et al. (2009) [37]	OCS	Australia	EMS + single hospital	OHCA	Mixed	28	15	Discharge
Don et al. (2009) [38]	OCS	USA	Single hospital	OHCA	External	313	122	Discharge
Derwall et al. (2009) [39]	OCS	Germany	EMS + single hospital	OHCA	Mixed	28	13	14 days
Testori et al. (2011) [12]	OCS	Austria	Single hospital	OHCA	Mixed	374	135	6 months
Dumas et al. (2011) [13]	OCS	France	Single hospital	OHCA	External	437	261	Discharge
Pfeifer et al. (2011) [40]	OCS	Germany	Single hospital	Mixed	Mixed	110	71	1 month
Storm et al. (2012) [41]	OCS	Germany	Single hospital	Mixed	Mixed	175	87	Discharge
Lundbye et al. (2012) [42]	OCS	USA	Single hospital	Mixed	Internal	100	52	ICU Discharge
Lindner et al. (2013) [14]	OCS	Norway	Single hospital	OHCA	Mixed	263	143	Discharge
Kozinski et al. (2013) [43]	OCS	Poland	Single hospital	OHCA	Internal	13	6	Discharge
Vaahersalo et al. (2013) [15]	OCS	Finland	Single hospital	OHCA	Mixed	223	70	Discharge/1 year
Perman et al. (2015) [16]	OCS	USA	Single hospital	Mixed	Unknown	519	262	Discharge
Doshi et al. (2016) [44]	OCS	USA	Multicenter	OHCA	Unknown	696	335	Discharge
Sung et al. (2016) [17]	OCS	USA	Single hospital	OHCA	Unknown	1423	596	Discharge

RCT: randomized controlled trials; OCS: observational cohort studies; OHCA: out-of-hospital cardiac arrest; EMS: emergency medical services.