The In Vitro Lipolysis of Lipid-Based Drug Delivery Systems: A Newly Identified Relationship between Drug Release and Liquid Crystalline Phase

Figure 3

The sequence of events that occur during (a) Type I, (b) Type II, (c) Type IIIA, (d) Type IIIB, and (e) Type IV lipid formulation lipolysis, respectively, has been observed via microscope (black arrow: lipid droplet; white arrow: liquid crystalline; and thick arrow: viscous isotropic). The photomicrographs ((a) to (e)) were taken from the same reaction sequence at 0, 1.5, 3.5, 5, 10, and 30 minutes, respectively. Scale bars (black line in (a)(A) and (d)(A)), 100 μm.