Extracellular Vesicles and Autophagy in Osteoarthritis

Figure 1

Some differences in the proteome and miRNA content in ACVs between OA and normal cartilage. These important findings are likely to become the basis for future accurate diagnoses and raise diagnosis precision to the molecular level in OA. The content of collagen type II, proteoglycan (PG), cartilage oligomeric matrix protein (COMP), fibronectin protein (FN), thrombospondin (TSP), and cartilage intermediate layer protein (CILP) in ACVs from a normal person is much higher than that from OA patients. The miRNA-140 content in OA patients is much lower than that in a normal person, while the miRNA-146 and miRNA-155 contents were found to be higher in OA patients than in normal persons.