Potential Diagnostic and Prognostic Biomarkers of Epigenetic Drift within the Cardiovascular Compartment

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left">Microvesicle type</td><td class="align_center">Size (<i>μ</i>m)</td><td class="align_left">Formation</td><td class="align_left">Internal composition</td><td class="align_left">External composition</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left">Exosome</td><td class="align_center">&lt;0.1</td><td class="align_left">Exocytosis</td><td class="align_left">Cytoplasm, protein, miRNA, mRNA</td><td class="align_left" rowspan="3">
                Plasma membrane and  surface proteins of parent cell</td></tr><tr><td class="align_left">Microparticle</td><td class="align_center">0.1–1.0</td><td class="align_left">Cell stress/stimuli<br/> Cell membrane asymmetry and cytoskeletal deregulation</td><td class="align_left">Cytoplasm, protein, miRNA, mRNA</td></tr><tr><td class="align_left">Apoptotic body</td><td class="align_center">&gt;1.0</td><td class="align_left">Apoptosis</td><td class="align_left">Cytoplasm, protein, miRNA, mRNA, nuclear fragments</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Microvesicle class based on size, origin, and composition.

BioMed Research International

tab1

Table 1

Table 1: Potential Diagnostic and Prognostic Biomarkers of Epigenetic Drift within the Cardiovascular Compartment 