| | Classification | Antimicrobial agents | Enzymes | Description | ESKAPE pathogens | | Bush-Jacoby | Ambler |
| | 1 | C | Narrow and extended-spectrum cephalosporins, including cephamycins | ACT-1, FOX-1, MIR-1, CMY | Cephalosporinases not inactivated by clavulanic acid | Enterobacter spp. | | 2a | A | Penicillins | PC1 | Penicillinases inactivated by clavulanic acid |
Enterobacteriaceae (e.g., K. pneumoniae, Enterobacter spp.) and nonfermenters (i.e., P. aeruginosa, A. baumannii) | | 2b | A | Penicillins, cephalothin | TEM-1, TEM-2, TEM-13, SHV-1, SHV-11 | Broad-spectrum enzymes inactivated by clavulanic acid | | 2be | A | Penicillins, oxyimino-cephalosporins (cefotaxime, ceftazidime, ceftriaxone, cefepime), monobactams | TEM-3, TEM-10, TEM-26, SHV-2, SHV-3, Klebsiella oxytoca K1, CTX-M, PER, VEB | Extended broad-spectrum enzymes inactivated by clavulanic acid | | 2br | A | Penicillins, resistant to clavulanic acid, tazobactam, sulbactam | TEM-30, TEM-31, SHV-10, SHV-72 | Broad-spectrum enzymes with reduced binding to clavulanic acid (inhibitor-resistant TEMs) | | | 2ber | A | Penicillins, oxyimino-cephalosporins, monobactams, resistant to clavulanic acid, tazobactam, sulbactam | TEM-50, TEM-158 | Extended-spectrum enzymes with relative resistance to clavulanic acid | | | 2c | A | Penicillins, carbenicillin | PSE-1, CARB-3 | Carbenicillin-hydrolyzing enzymes inactivated by clavulanic acid | | | 2ce | A | Carbenicillin, cefepime | RTG-4 (CARB-10) | Extended-spectrum carbenicillinase | | | 2d | D | Cloxacillin, oxacillin | OXA-1, OXA-2, OXA-10 | Cloxacillin-hydrolyzing enzymes with variable inactivation by clavulanic acid | | | 2de | D | Cloxacillin, oxacillin, oxyimino-cephalosporins, monobactams | OXA-11, OXA-15 | | | 2df | D | Cloxacillin, oxacillin, carbapenems | OXA-23, OXA-51, OXA-58 | | | 2e | A | Cephalosporins | CepA | Cephalosporinases inactivated by clavulanic acid | | | 2f | A | All -lactams, including carbapenems | KPC, SME, GES, IMI-1 | Carbapenem-hydrolyzing non-metallo--lactamases | | | 3 | B | All -lactams, including carbapenems, with exception of monobactams | IMP, VIM, IND | Metallo--lactamases | | | 4 | — | Penicillins | Penicillinases from Burkholderia cepacia | Penicillinases not inactivated by clavulanic acid | |
|
|
