| Variables | Number of studies | RR (95% CI) | % | |
| Overall | 7 | 1.65 (1.26, 2.16) | 76.2 | 0.000 | Location | | | | | US | 4 | 1.69 (1.27, 2.24) | 50.3 | 0.110 | Europe | 3 | 1.72 (0.83, 3.58) | 78.5 | 0.000 | Follow-up years | | | | | <10 | 3 | 1.37 (1.11, 1.69) | 0.0 | 0.543 | ≧10 | 4 | 1.88 (1.15, 3.07) | 86.5 | 0.000 | Sex | | | | | Female | 5 | 1.60 (1.18, 2.16) | 78.8 | 0.000 | Male | 4 | 1.42 (1.00, 2.02) | 50.9 | 0.106 | Both sex | 1 | 1.59 (0.60, 4.22) | NA | NA | Number of participants | | | | | <50000 | 4 | 1.47 (1.22, 1.76) | 0.0 | 0.402 | ≧50000 | 3 | 1.96 (0.96, 4.01) | 88.0 | 0.000 | Number of cases | | | | | <400 | 5 | 2.07 (1.62, 2.64) | 0.0 | 0.569 | ≧400 | 2 | 1.16 (1.04, 1.29) | 23.6 | 0.252 | Study quality | | | | | Moderate | 2 | 1.69 (0.93, 3.06) | 77.9 | 0.034 | High | 5 | 1.71 (1.14, 2.56) | 76.9 | 0.000 | Adjustment for confounders | | | | | Number of confounders | | | | | <4 | 3 | 1.39 (1.01, 1.91) | 80.0 | 0.007 | ≧4 | 4 | 1.94 (1.49, 2.51) | 0.0 | 0.812 | Alcohol | | | | | Yes | 3 | 1.97 (1.50, 2.57) | 0.0 | 0.675 | No | 4 | 1.39 (1.04, 1.86) | 71.1 | 0.016 | Smoking | | | | | Yes | 3 | 2.06 (1.43, 2.96) | 0.0 | 0.690 | No | 4 | 1.49 (1.11, 2.01) | 80.7 | 0.001 | Weight | | | | | Yes | 2 | 1.83 (1.33, 2.50) | 0.0 | 0.976 | No | 5 | 1.58 (1.15, 2.17) | 77.7 | 0.001 |
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