HIV-1 Epidemiology, Genetic Diversity, and Primary Drug Resistance in the Tyumen Oblast, Russia

Table 1

Epidemic and clinical characteristics of HIV-infected individuals involved in the study and genotyping data on the isolated HIV-1 variants.

Number	Gender	Age,; years	Date last tested negative	Date first tested positive	Assumed time of infection	Transmission risk group	Types of drugs	Plasma; HIV-1 RNA copies/mL	CD4^+ T cell count, cells/mm^3	HIV-1 tropism	HIV-1 genotype
1	M	38	2005	14.02.2007	2005–2007	CSW	O, H	7490	394	CCR5	A
2	F	37	ND	14.09.2011	2010-2011	CSW	Sy	20 200	332	CCR5	A
3	F	27	2013	17.09.2015	2013–2015	HTs	—	4050	296	CCR5	A
4	F	31	ND	22.09.2015	2011–2013	HTs	—	1340	599	CCR5	A
5	M	36	2012	05.08.2014	2012–2014	IDU	O, H, Sy	132 000	199	CCR5	A
6	F	33	2003	24.09.2015	2003–2015	HTs	—	4020	428	CXCR4	A
7	M	39	2012	24.10.2012	2012	IDU	O, H, Sy	43 900	232	CCR5	A
8	M	37	ND	08.05.2001	2000	IDU	H	110 000	2	CXCR4	A
9	M	32	2010	29.09.2015	2011–2015	IDU	O, H, Sy	548	253	ССR5	A
10	F	35	2009	01.07.2015	2009–2015	IDU	H	15 900	210	NA	A
11	M	38	ND	01.10.2015	2015	MSM	—	1060 000	284	CCR5	В
12	M	30	2015	24.09.2015	2014-2015	IDU	S	1080	413	CCR5	A
13	M	34	2015	09.10.2015	2015	HTs	—	36 100	1105	CCR5	A
14	F	36	2009	18.09.2015	2009–2015	HTs	—	2670	266	CCR5	A
15	F	40	2013	17.09.2015	2013–2015	HTs	—	43 700	332	NA	A
16	M	33	2006	16.10.2015	2007–2015	HTs	—	7100	285	CCR5	A
17	F	40	2015	02.10.2015	2014-2015	IDU	S, H, Sy	4490	353	NA	A
18	M	31	2009	06.10.2015	2009–2015	IDU	Sy	7150	243	NA	A
19	M	36	ND	19.03.2015	2001–2015	IDU	H, S	500	74	NA	CRF63_02A1
20	F	24	ND	29.09.2015	2010–2015	HTs	—	1120	500	CCR5	A
21	M	36	ND	15.11.2000	1999-2000	IDU	O, H	293 000	159	CCR5	A
22	M	34	2014	17.12.2014	2013-2014	HTs	—	5070	617	NA	CRF03_AB
23	F	28	ND	28.11.2011	2007–2010	IDU	H, S	217 000	398	CCR5	A
24	F	34	ND	15.10.2015	2013–2015	IDU	S	11 500	318	CCR5	A
25	F	34	2011	25.08.2015	2011–2015	HTs	—	500	666	NA	A
26	F	27	ND	15.10.2015	2012–2015	HTs	—	32 700	254	CCR5	A
27	F	30	2015	05.10.2015	2014-2015	IDU	S	22 960	641	NA	A
28	F	41	2013	19.10.2015	2013–2015	HTs	—	94 000	745	NA	A
29	M	39	ND	20.06.2002	2001	IDU	H	41 200	1240	NA	A
30	M	36	ND	29.04.2010	2010	IDU	H	239 000	250	NA	A
31	M	37	ND	20.12.2006	2002–2005	IDU	H	1150 000	90	CCR5	URF63_A1
32	F	34	ND	14.04.2014	2007–2010	HTs	—	11 400	296	NA	A
33	M	36	ND	23.07.2015	2012–2014	IDU	S	78 400	211	CCR5	URF63_A1
34	F	45	ND	02.10.2015	2007–2010	HTs	—	160 000	358	NA	A
35	F	36	2013	22.10.2015	2013-2014	IDU	H, S	4270	317	CCR5	A
36	M	45	2002	19.10.2015	2002–2015	IDU	O, H	88 400	208	CCR5	A
37	F	47	2013	11.11.2013	2012-2013	IDU	H, S	83 700	262	CXCR4	A
38	F	29	2007	26.10.2015	2007–2015	HTs	—	45 200	236	CXCR4	A
39	M	43	2013	09.10.2015	2013–2015	IDU	H, S	57900	494	CCR5	A
40	M	44	2009	01.10.2015	2009–2015	HTs	—	234 000	203	CCR5	A
41	M	26	ND	08.10.2013	2012-2013	IDU	S	9640	317	NA	А
42	F	35	2013	15.10.2015	2013–2015	HTs	—	24 100	859	CCR5	A
43	M	42	ND	23.07.2015	2008–2015	HTs	—	7040 000	114	CXCR4	A
44	F	31	2010	27.10.2015	2010–2015	HTs	—	60 400	452	CXCR4	A
45	F	25	2014	23.10.2015	2014-2015	HTs	—	20 200	376	NA	NA
46	M	36	2014	05.10.2015	2014-2015	HTs	—	344 000	470	CCR5	A
47	F	19	ND	23.10.2015	2013–2015	HTs	—	500	588	NA	NA
48	F	33	ND	01.10.2015	2014-2015	HTs	—	118 000	393	CCR5	A
49	F	31	ND	08.10.2015	2005–2015	HTs	—	110 000	290	CCR5	A
50	F	33	ND	19.10.2015	2010–2015	HTs	—	500	901	NA	А
51	F	36	ND	15.10.2015	2013-2014	HTs	—	10 500	1006	NA	A
52	M	34	ND	22.10.2015	2010–2015	HTs	—	138 000	197	CCR5	A
53	M	29	ND	19.10.2015	2003–2015	IDU	H, S, Sy	56 000	700	NA	A
54	F	47	ND	06.11.2015	2005–2015	HTs	—	15 800	589	CCR5	A
55	F	28	2013	17.09.2015	2013–2015	HTs	S	22 000	802	CCR5	A
56	M	37	ND	29.10.2015	2002–2015	HTs	—	225 000	434	CCR5	A
57	F	37	2008	23.10.2015	2010–2015	HTs	—	869	901	NA	A
58	F	33	ND	19.10.2015	2012–2015	HTs	—	12 100	205	CCR5	A
59	F	45	ND	21.08.2013	2012-2013	IDU	H, S	8720	193	CXCR4	A
60	F	32	2013	10.11.2015	2014-2015	IDU	S	500	281	CXCR4	A
61	M	35	ND	02.11.2015	2000–2005	IDU	H, S, Sy	33 800	181	NA	A
62	M	61	ND	11.11.2015	2010–2015	HTs	—	16200	206	NA	A
63	M	41	2013	02.11.2015	2013-2014	HTs	—	2210	379	CCR5	А
64	M	32	2013	06.10.2015	2014	IDU	H, S, Sy	41 800	450	CCR5	A
65	F	43	2012	06.11.2015	2012-2013	HTs	—	35 600	117	CXCR4	A
66	M	32	2010	09.11.2015	2015	IDU	H	671 000	277	CXCR4	A
67	F	37	2014	27.10.2015	2014-2015	HTs	—	18 400	411	CCR5	A
68	F	25	2014	20.11.2015	2014-2015	HTs	—	34 300	325	CCR5	A
69	F	37	2013	20.11.2015	2015	IDU	O, Sy, H, S	21 200	575	CCR5	A
70	F	37	2014	10.11.2015	2014-2015	HTs	—	8780	461	CCR5	A
72	M	39	2013	10.08.2015	2013–2015	HTs	—	283 000	46	CCR5	A
73	F	34	2014	24.07.2015	2014-2015	HTs	—	1110	942	NA	A
74	M	55	2013	06.11.2015	2013–2015	HTs	—	6810	707	CCR5	А
75	F	36	2003	30.11.2015	2014-2015	HTs	—	11 000	614	CCR5	А

M: male and F: female. Data at the time of HIV-negative diagnosis. Data at the time of HIV-positive diagnosis.
Assumed time of infection determined after individual interview with epidemiologist. Transmission risk groups; CSW: commercial sex worker; IDU: injection drug user; MSM: man having sex with man, and HTs: heterosexual contacts. Types of used drugs: H: heroin; O: other opioids; S: salt; and Sy: synthetic. Prediction using Geno2pheno 2.5 software and WebPSSM. ND: not detected; NA: not amplified.