Effects of Berberine on NLRP3 and IL-1β Expressions in Monocytic THP-1 Cells with Monosodium Urate Crystals-Induced Inflammation

Figure 4

Immunofluorescence for NLRP3. N: normal group; M: model group; 3.125 μM Ber, 6.25 μM Ber, 12.5 μM Ber, and 25 μM Ber: berberine group (Ber) of different concentrations. NLRP3: domain present in neuronal apoptosis inhibitor protein major histocompatibility complex class II transactivator, leucine rich repeat, and pyrin domains-containing protein 3. The protein expression of NLRP3 was mainly located in the cytoplasm (green). The nuclei were stained with blue by DAPI.