Use of Adipose-Derived Stem Cells to Support Topical Skin Adhesive for Wound Closure: A Preliminary Report from Animal In Vivo Study

Figure 5

Histological assessment results. (a) Study Group scars were composed of dense collagen and spindle-shaped fibroblasts (proliferation of fibroblasts at the bottom of the scar) with preserved, singular vascular channels. Giant-cell, foreign-body type (residual features of the resorptive process) adipose tissue under the scar mummified/calcified cells mainly along the scar and blood vessels; magnification 2x. (b) In control group C1 scar tissue was composed of dense collagen and moderate numbers of spindle-shaped fibroblasts, with some mummified/calcified cells, mainly inside the scar (magnification 10x). (c) In the histological assessment of second control group C2, the scar tissue was composed of dense collagen with characteristic calcification of cells located especially in the central zone of the scar (magnification 2x). (d) In C3 group, the scar was composed of dense collagen and spindle-shaped fibroblasts with preserved, singular vascular channels and giant-cell, foreign-body type cells (residual features of the resorptive process), magnification 2x. (e) In C4 group, the scar was composed of dense collagen and spindle-shaped fibroblasts with preserved, singular vascular channels and hyperkeratosis of epidermis above the scar, magnification 2x. (f) In C5 group, the natural, untreated scar formation was composed of dense collagen and spindle-shaped fibroblasts with preserved singular vascular channels and foreign-body granuloma at the bottom of the scar, magnification 2x.

(a)

(b)

(c)

(d)

(e)

(f)