Research Article
Comparison of FDA Approved Kinase Targets to Clinical Trial Ones: Insights from Their System Profiles and Drug-Target Interaction Networks
Figure 1
Drug-target interaction network of FDA approved drugs targeting kinase. Single target drugs were represented by round rectangle (small molecular drugs in orange, monoclonal antibodies in magenta, and biologics in green), while multitarget drugs were represented by orange hexagon and highlighted by additional orange hexagon line. All kinase targets were shown by blue ellipse. Interactions between drug and target were displayed by edges with shapes of arrow and âTâ representing activation and inhibition, respectively.