Comparison of FDA Approved Kinase Targets to Clinical Trial Ones: Insights from Their System Profiles and Drug-Target Interaction Networks

Figure 2

Drug-target interaction network of kinase inhibitors in clinical trial—a subnetwork of the malignant neoplasms of female genital organs (C51–C58). Single target drugs were shown as a round rectangle, while the multitarget drugs were displayed by hexagon. Colors of the drugs were defined as follows: phase 2 clinical trial drugs are in green and phase 1 clinical trial drugs are in yellow. The multitarget drugs were highlighted by an additional orange hexagon line. Established and clinical trial targets were shown by blue and violet ellipses, respectively.