Antipsychotic Drugs Inhibit Platelet Aggregation via P2Y₁ and P2Y₁₂ Receptors

Figure 8

The effect of chronic APDs on APD-induced TXA₂ and arachidonic acid production in platelets from rats. Chronic APD-treated PRPs were produced by treating rats with the indicated concentration of APDs as described in Section 2. Isolated platelets were harvested at day 28 and then stimulated with 3 μM fibrinogen and 10 μM ADP at 37°C for 3 minutes. Reactions were stopped and the content of thromboxane B₂ (a) or arachidonic acid (b) was measured using an enzyme immunoassay. Data represent the mean ± SEM (). value < 0.05 for cells treated with chronic APDs followed by fibrinogen and ADP stimulation compared to control cells stimulated with fibrinogen and ADP alone.

(a)

(b)