Antipsychotic Drugs Inhibit Platelet Aggregation via P2Y1 and P2Y12 Receptors
Table 1
ROTEM measurements of EXTEM in blood treated with APDs ().
Parameters
Control
Risperidone
Clozapine
Haloperidol
Coagulation activation and clot polymerization parameters
Coagulation time (seconds)
60 ± 4.6
71.3 ± 25.6
69.7 ± 26
53.3 ± 25.1
Clot formation time (seconds)
115.3 ± 7.6
171.7 ± 19.3
169 ± 11.1
151.3 ± 33.2
α-angle (degree)
68.7 ± 0.6
58 ± 2.6
58.3 ± 1.5
61.3 ± 5.8
Clot firmness parameters (mm)
Amplitude at 5 min (A5)
45.3 ± 1.5
30.3 ± 0.6
30.7 ± 0.6
35 ± 5.2
A10
58 ± 1
42.3 ± 0.6
43 ± 1
47 ± 5.3
A15
62.3 ± 0.6
47.7 ± 0.6
48 ± 1
52.3 ± 4.2
A20
64.3 ± 0.6
50.7 ± 0.6
51.7 ± 1.5
55.3 ± 4.2
A25
64.3 ± 0.6
52.7 ± 0.6
53.3 ± 2.1
57 ± 3.6
A30
63 ± 1
53.7 ± 0.6
54.3 ± 2.1
57.7 ± 3.1
Maximum clot firmness (MCF)
64.7 ± 0.6
54.3 ± 0.6
54.7 ± 2.5
57.7 ± 3.1
ROTEM: rotation thromboelastometry; EXTEM: extrinsically activated assay using recombinant tissue factor. The data are expressed as the median (interquartile range). compared with the control group.
