Potential Role of Epigenetic Mechanism in Manganese Induced Neurotoxicity

Figure 1

The specific regions of the brain influenced via manganese exposure depending on the level and potential of exposure. Globus pallidus is a major part of basal ganglia region of brain that includes substantia nigra. Dopamine is an important neurotransmitter, produced in the brain mainly by dopaminergic neurons in substantia nigra. The progressive loss of dopaminergic neurons due to manganese accumulation in substantia nigra over the prolonged exposure period leads to development of parkinsonism. Manganism happens on high acute exposure and accumulation of manganese, specifically in the globus pallidus.