Evaluation of Neuroprotective Effect of Thymoquinone Nanoformulation in the Rodent Cerebral Ischemia-Reperfusion Model

Figure 1

(a) DSC thermogram of TQ, PLGA, and physical mixture of TQ-PLGA and TQ loaded PLGA nanoparticles, respectively. TQ was molecularly distributed with the PLGA polymer and entrapped within PLGA-CN nanoparticle matrix; therefore the characteristic peaks of TQ (45–47°C) and PLGA (~120°C) were not seen in TQ-PLGA nanoparticles. (b) The in vitro release of TQ-PLGA nanoparticles. It showed a biphasic release with 16% TQ release within 1 h followed by characteristic sustained release for more than 24 h.

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(b)