Evaluation of Neuroprotective Effect of Thymoquinone Nanoformulation in the Rodent Cerebral Ischemia-Reperfusion Model

Table 1

Concentration of ingredients and physiochemical parameter of the optimized thymoquinone loaded PLGA nanoparticles.

Conc. of polymers	Conc. of stabiliser	Conc. of drug (mg/mL)	Mean particle size (nm ± SD)	Mean PDI (±SD)	Zeta potential (mV ± SD)	EE% (±SD)	LC%; (±SD)
1 mg/mL	0.25 mg/mL (CN); 0.25 mg/mL (PVA)	0.3 mg/mL	183.5 ± 8.2	0.257 ± 0.02	33.63 ± 2.25	73.2 ± 2.6	31.4 ± 2.1

The optimized TQ-PLGA nanoparticles had PLGA : stabiliser : TQ ratio of 1 : 0.5 : 0.3 with mean particle size of 183.5 nm, polydispersity index (PDI) of 0.25, and zeta potential of +33.6 mV. The average encapsulation efficiency and loading capacity of TQ-PLGA nanoparticles were found to be 73.2% and 31.4%, respectively.