Evaluation of Neuroprotective Effect of Thymoquinone Nanoformulation in the Rodent Cerebral Ischemia-Reperfusion Model

Table 3

Effect of thymoquinone loaded PLGA nanoparticles on the catalase and SOD activity in the brain of MCAO rats.

Groups	Treatment	Catalase; ( moles of H2O2/min/mg protein)	SOD; (U/mg protein)
1	Sham control	3.81 ± 0.112	7.30 ± 0.031
2	MCAO control	1.54 ± 0.106	4.53 ± 0.311
3	MCAO + TQ PLGA NPs (i.n.)	3.64 ± 0.054	7.01 ± 0.078
4	MCAO + TQ solution (i.n.)	2.06 ± 0.018	5.57 ± 0.031
5	MCAO + TQ solution (oral)	1.96 ± 0.021	5.49 ± 0.084

The intranasal delivery of TQ-PLGA nanoparticles led to significant increase in the antioxidant enzymes catalase and SOD in the MCAO rats when compared to TQ solution delivered by intranasal or oral route alone. ; data represent mean ± SEM; versus sham control;   versus MCAO control; and   versus MCAO control.