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BioMed Research International
Volume 2016, Article ID 2571080, 9 pages
http://dx.doi.org/10.1155/2016/2571080
Review Article

Effect of Ulinastatin in the Treatment of Postperative Cognitive Dysfunction: Review of Current Literature

Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

Received 12 March 2016; Revised 8 June 2016; Accepted 9 June 2016

Academic Editor: Fabrizio Montecucco

Copyright © 2016 Zheng-tao Lv et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Deiner and J. H. Silverstein, “Postoperative delirium and cognitive dysfunction,” British Journal of Anaesthesia, vol. 103, supplement 1, pp. i41–i46, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. T. L. Tsai, L. P. Sands, and J. M. Leung, “An update on postoperative cognitive dysfunction,” Advances in Anesthesia, vol. 28, pp. 269–284, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. D. van Dijk, A. M. A. Keizer, J. C. Diephuis, C. Durand, L. J. Vos, and R. Hijman, “Neurocognitive dysfunction after coronary artery bypass surgery: a systematic review,” Journal of Thoracic and Cardiovascular Surgery, vol. 120, no. 4, pp. 632–639, 2000. View at Publisher · View at Google Scholar · View at Scopus
  4. T. G. Monk and C. C. Price, “Postoperative cognitive disorders,” Current Opinion in Critical Care, vol. 17, no. 4, pp. 376–381, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. N. Terrando, C. Monaco, D. Ma, B. M. J. Foxwell, M. Feldmannc, and M. Maze, “Tumor necrosis factor-a triggers a cytokine cascade yielding postoperative cognitive decline,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 47, pp. 20518–20522, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. N. Terrando, L. I. Eriksson, J. K. Ryu et al., “Resolving postoperative neuroinflammation and cognitive decline,” Annals of Neurology, vol. 70, no. 6, pp. 986–995, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. X. Su, X. Feng, N. Terrando et al., “Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome,” Molecular Medicine, vol. 18, no. 12, pp. 1481–1490, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. V. Degos, S. Vacas, Z. Han et al., “Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction,” Anesthesiology, vol. 118, no. 3, pp. 527–536, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. Y.-H. Zhang, X.-H. Guo, Q.-M. Zhang, G.-T. Yan, and T.-L. Wang, “Serum CRP and urinary trypsin inhibitor implicate postoperative cognitive dysfunction especially in elderly patients,” International Journal of Neuroscience, vol. 125, no. 7, pp. 501–506, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. B. M. Stalnacke and P. Sojka, “S100B for diagnosis and prognosis of sequelae following minor head injury. Contradictory results according to studies,” Lakartidningen, vol. 105, no. 24-25, pp. 1840–1845, 2008. View at Google Scholar
  11. K.-I. Inoue, H. Takano, A. Shimada et al., “Urinary trypsin inhibitor protects against systemic inflammation induced by lipopolysaccharide,” Molecular Pharmacology, vol. 67, no. 3, pp. 673–680, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. K.-I. Inoue and H. Takano, “Urinary trypsin inhibitor as a therapeutic option for endotoxin-related inflammatory disorders,” Expert Opinion on Investigational Drugs, vol. 19, no. 4, pp. 513–520, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. C.-C. Chen, S.-S. Wang, and F.-Y. Lee, “Action of antiproteases on the inflammatory response in acute pancreatitis,” Journal of the Pancreas, vol. 8, no. 4, supplement, pp. 488–494, 2007. View at Google Scholar · View at Scopus
  14. R. Sun, Y. Li, W. Chen, F. Zhang, and T. Li, “Total ginsenosides synergize with ulinastatin against septic acute lung injury and acute respir atory distress syndrome,” International Journal of Clinical and Experimental Pathology, vol. 8, no. 6, pp. 7385–7390, 2015. View at Google Scholar · View at Scopus
  15. S. S. Atal and S. Atal, “Ulinastatin—a newer potential therapeutic option for multiple organ dysfunction syndrome,” Journal of Basic and Clinical Physiology and Pharmacology, vol. 27, no. 2, 2016. View at Publisher · View at Google Scholar
  16. Y. Li, L. Zhao, H. Fu, Y. Wu, and T. Wang, “Ulinastatin suppresses lipopolysaccharide induced neuro-inflammation through the downregulation of nuclear factor-κB in SD rat hippocampal astrocyte,” Biochemical and Biophysical Research Communications, vol. 458, no. 4, pp. 763–770, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. S. J. Kim, K. Y. Yoo, C. W. Jeong et al., “Urinary trypsin inhibitors afford cardioprotective effects through activation of PI3K-Akt and ERK signal transduction and inhibition of p38 MAPK and JNK,” Cardiology, vol. 114, no. 4, pp. 264–270, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. W. Li, X. Qiu, H. Jiang, Y. Zhi, J. Fu, and J. Liu, “Ulinastatin inhibits the inflammation of LPS-induced acute lung injury in mice via regulation of AMPK/NF-κB pathway,” International Immunopharmacology, vol. 29, no. 2, pp. 560–567, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. X. Zhang, F. Liu, H. Liu et al., “Urinary trypsin inhibitor attenuates lipopolysaccharide-induced acute lung injury by blocking the activation of p38 mitogen-activated protein kinase,” Inflammation Research, vol. 60, no. 6, pp. 569–575, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Shu, Y. Yang, W. Qiu et al., “Neuroprotection by ulinastatin in experimental autoimmune encephalomyelitis,” Neurochemical Research, vol. 36, no. 11, pp. 1969–1977, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Koga, M. Fujita, R. Tsuruta et al., “Urinary trypsin inhibitor suppresses excessive superoxide anion radical generation in blood, oxidative stress, early inflammation, and endothelial injury in forebrain ischemia/reperfusion rats,” Neurological Research, vol. 32, no. 9, pp. 925–932, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. D. Moher, A. Liberati, J. Tetzlaff, D. G. Altman, and P. Group, “Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement,” PLoS Medicine, vol. 6, no. 7, Article ID e1000097, 2009. View at Publisher · View at Google Scholar
  23. J. P. T. Higgins and S. Green, Eds., Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0, The Cochrane Collaboration, 2011, http://handbook.cochrane.org/.
  24. Y.-Y. Ge, Y. Xu, J.-Q. Cheng, J.-M. Chen, R.-M. Xu, and Y.-D. Jiang, “Case-control study on the effect of ulinastatin on postoperative complications in elderly patients undergoing hip joint replacement,” China Journal of Orthopaedics and Traumatology, vol. 24, no. 6, pp. 459–462, 2011 (Chinese). View at Google Scholar · View at Scopus
  25. Y.-M. Kang, Y.-Y. Ge, J.-Q. Cheng et al., “Effect of ulinastatin on post-operative cognition disorders in elderly patients undergoing hip joint replacement,” China Journal of Orthopaedics and Traumatology, vol. 23, no. 5, pp. 355–358, 2010. View at Google Scholar · View at Scopus
  26. L.-L. Xu, Z.-Y. Hu, and J.-J. Shen, “A preliminary study of the effects of ulinastatin on early postoperative cognition function in patients undergoing abdominal surgery,” Neuroscience Letters, vol. 541, pp. 15–19, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. X. Shan, X. Zhang, X. Li, G. Xu, and Z. Li, “Effect of ulinastatin on postoperative cognitive function in the elderly with fracture,” National Medical Journal of China, vol. 95, no. 20, pp. 1586–1589, 2015 (Chinese). View at Publisher · View at Google Scholar · View at Scopus
  28. Y.-L. Ge, H.-W. Shi, W.-F. Zhu et al., “Effects of ulinastatin on cognitive function in patients with coronary artery bypass grafting,” Zhejiang Da Xue Xue Bao Yi Xue Ban, vol. 44, no. 5, pp. 532–538, 2015. View at Google Scholar
  29. S. P. Newman, “Analysis and interpretation of neuropsychologic tests in cardiac surgery,” The Annals of Thoracic Surgery, vol. 59, no. 5, pp. 1351–1355, 1995. View at Publisher · View at Google Scholar · View at Scopus
  30. G. L. Boos, L. F. Soares, and G. R. De Oliveira Filho, “Postoperative cognitive dysfunction: prevalence and associated factors,” Revista Brasileira de Anestesiologia, vol. 55, no. 5, pp. 517–524, 2005. View at Google Scholar · View at Scopus
  31. T. Johnson, T. Monk, L. S. Rasmussen et al., “Postoperative cognitive dysfunction in middle-aged patients,” Anesthesiology, vol. 96, no. 6, pp. 1351–1357, 2002. View at Publisher · View at Google Scholar · View at Scopus