|
| Study | Study design | Population | Intervention and control | Outcomes |
|
| Xu et al., 2013 China [26] | Prospective, double-blind,
2-arm RCT | Abdominal surgery under intravenous general anesthesia;
U: 40 patients, 75.6 ± 7.2 years;
C: 40 patients, 74.1 ± 8.1 years | U: ulinastatin 10000 units/kg diluted in normal saline to a volume of 100 mL (i.v.), over a period of 30 min before surgical incision and 5000 units/kg after surgery on days 1–3;
C: 100 mL normal saline (i.v.) | Incidence of POCD;
IL-6, TNF-α, CRP, S100β |
|
| Ge et al., 2011 China [24] | 2-arm RCT | Hip joint replacement under combined spinal-epidural anesthesia;
U: 80 patients, 72.8 ± 7.5 years;
C: 80 patients, 75.0 ± 7.1 years | U: ulinastatin 10000 units/kg diluted in normal saline to a volume of 50 mL (i.v.), over a period of 30 min before surgical incision and 5000 units/kg after surgery on days 1–3;
C: 50 mL normal saline (i.v.) | Incidence of POCD |
|
| Kang et al., 2010 China [25] | 2-arm RCT | Hip joint replacement under combined spinal-epidural anesthesia;
U: 40 patients, 75.0 ± 7.81 years;
C: 40 patients, 72.8 ± 7.25 years | U: ulinastatin 10000 units/kg diluted in normal saline to a volume of 50 mL (i.v.), over a period of 30 min before surgical incision and 5000 units/kg after surgery on days 1–3;
C: 50 mL normal saline (i.v.) | Incidence of POCD,
MMSE score;
S100β |
|
| Shan et al., 2015 China [27] | 2-arm RCT | Hip fracture under combined spinal-epidural anesthesia;
U: 21 patients, 78 ± 2 years;
C: 27 patients, 75 ± 1 years | U: ulinastatin 5000 units/kg diluted in normal saline to a volume of 100 mL (i.v.), before surgical incision and 5000 units/kg immediately after surgery;
C: 100 mL normal saline (i.v.) | Incidence of POCD,
MMSE score;
CRP |
|
| Ge et al., 2015 China [28] | 3-arm RCT | Coronary artery bypass grafting under intravenous general anesthesia;
U1: 31 patients, 69.1 ± 4.8 years;
U2: 30 patients, 68.9 ± 4.7 years;
C: 32 patients, 67.7 ± 5.4 years | U1: ulinastatin 16000 units/kg diluted in normal saline to a volume of 60 mL (i.v.) before anesthesia induction;
U2: ulinastatin 8000 units/kg diluted in normal saline to a volume of 60 mL (i.v.) before anesthesia induction;
C: 60 mL normal saline (i.v.) | Incidence of POCD;
IL-6, TNF-α, CRP, S100β |
|
