Menoprogen, a TCM Herbal Formula for Menopause, Increases Endogenous E₂ in an Aged Rat Model of Menopause by Reducing Ovarian Granulosa Cell Apoptosis

Table 2

Effects of treatments on serum E₂ levels in NAM rats as compared with normal 4-month-old female rats and untreated NAM rats () ( per arm).

Rat group	E2 (pg/mL)
	Before treatment	After treatment
Normal control	72.80 ± 28.29	69.78 ± 19.68
NAM (untreated)	38.23 ± 11.50	39.68 ± 13.32
Low-dose	45.17 ± 15.63	66.41 ± 14.27
Middle-dose	48.81 ± 27.63	92.50 ± 23.88
High-dose	40.84 ± 10.17	70.50 ± 9.34
Progynova	42.01 ± 13.07	71.36 ± 8.96

⁢ < 0.01 versus normal control group; < 0.001 versus NAM group.