Resistance to Second-Line Antituberculosis Drugs and Delay in Drug Susceptibility Testing among Multidrug-Resistant Tuberculosis Patients in Shanghai
Table 4
Multivariate analysis of resistance to second-line drugs in longer/shorter total and health system delay in DST completion, stratified by residence and TB history.
Variables
Adjusted OR (95% CI) for a delay longer than median days
Resistance to SLDs
Resistance to Ofx
Resistance to Am/Km
Resistance to Cm
XDR-TB
Total delay in DST completion
Residence
Local
2.35 (1.08–5.11)
2.15 (0.97–4.76)
1.29 (0.53–3.14)
1.46 (0.59–3.63)
1.50 (0.57–3.97)
Domestic migrant
2.31 (0.79–6.81)
1.81 (0.52–6.36)
0.82 (0.14–4.71)
1.38 (0.36–5.34)
0.64 (0.10–4.16)
TB history
Newly diagnosed
1.51 (0.54–4.23)
1.00 (0.33–3.08)
0.88 (0.26–3.01)
1.21 (0.39–3.82)
0.83 (0.23–3.01)
Relapsed
1.81 (0.69–4.73)
2.78 (0.88–8.82)
1.71 (0.38–7.69)
1.21 (0.32–4.49)
2.46 (0.50–12.17)
Chronic
7.14 (1.46–35.00)
4.65 (1.03–21.08)
1.27 (0.25–6.45)
2.75 (0.26–29.45)
1.39 (0.20–9.88)
Health system delay in DST completion
Residence
Local
3.93 (1.71–9.07)
2.93 (1.28–6.70)
1.24 (0.52–3.00)
1.70 (0.68–4.26)
1.50 (0.58–3.91)
Domestic migrant
2.64 (0.91–7.63)
2.19 (0.65–7.42)
0.94 (0.17–5.31)
1.47 (0.38–5.78)
0.80 (0.13–4.97)
TB history
Newly diagnosed
1.61 (0.56–4.63)
1.38 (0.44–4.33)
0.86 (0.25–3.01)
0.83 (0.26–2.71)
0.80 (0.21–3.01)
Relapsed
5.75 (1.89–17.52)
5.01 (1.39–18.05)
2.10 (0.45–9.76)
3.39 (0.81–14.16)
3.70 (0.65–21.10)
Chronic
5.09 (1.01–25.70)
4.95 (1.12–21.82)
1.38 (0.29–6.64)
2.18 (0.23–20.92)
1.51 (0.23–9.88)
OR, odds ratio; CI, confidence interval; SLDs, second-line drugs; Ofx, ofloxacin; Am, amikacin; Km, kanamycin; Cm, capreomycin; XDR-TB, extensively drug-resistant tuberculosis; DST, drug susceptibility testing. ORs were adjusted for age at diagnosis (continuous), sex, and level of TB hospital. .
