DASAF: An R Package for Deep Sequencing-Based Detection of Fetal Autosomal Abnormalities from Maternal Cell-Free DNA

Figure 2

-score distribution for maternal cell-free DNA samples at varying sequencing depths. The black dots represent samples from the 100 bp pair-end run at a depth of 12 M reads. The black squares, diamonds, and triangles represent samples from the original 100 bp paired end run that have been randomly subsampled to 7 M, 5 M, and 3 M reads, respectively. The black line indicates the -score threshold of 3.