BioMed Research International

Review Article

Differences in Rhodococcus equi Infections Based on Immune Status and Antibiotic Susceptibility of Clinical Isolates in a Case Series of 12 Patients and Cases in the Literature

Table 5

Comparison of antibiotic susceptibilities of R. equi isolated from patients in Europe and the United States in the six studies under analysis.


Antibiotic	Europe				Subtotal (%)	United States		Subtotal (%)	value	Total (%)
Antibiotic	Donisi et al. [12]	Arlotti et al. [11]	Torres-Tortosa et al. [16]	Topino et al. [13]	Subtotal (%)	Scott et al. [14]	U of Kentucky	Subtotal (%)	value	Total (%)

Clarithromycin	NA	NA	NA	6/6^†	6/6 (100)	NA	6/6	6/6 (100)	NS	12/12 (100)
Vancomycin	9/9	21/21	60/60	8/9	98/99 (99)	9/9	10/10	19/19 (100)	NS	117/118 (99)
Rifampin	1/2	21/21	47/48	6/8	75/79 (95)	NA	6/7	6/7 (86)	NS	81/86 (94)
Amikacin	NA	9/9	22/22	4/6	35/37 (95)	9/9	6/7	15/16 (94)	NS	50/53 (94)
Erythromycin	6/9	24/24	53/58	6/6	89/97 (92)	9/9	5/5	14/14 (100)	NS	103/111 (93)
Teicoplanin	8/8	9/9	NA	6/8	23/25 (92)	NA	NA	NA	NA	23/25 (92)
Imipenem	2/2	17/21	41/42	7/7	67/72 (93)	NA	4/6	4/6 (67)	NS	71/78 (91)
Netilmicin	8/8	8/9	NA	4/5	20/22 (91)	NA	NA	NA	NA	20/22 (91)
Gentamicin	NA	15/15	40/47	5/7	60/69 (87)	9/9	5/5	14/14 (100)	NS	74/83 (89)
Ciprofloxacin	6/9	11/19	47/50	8/9	72/87 (83)	9/9	6/6	15/15 (100)	NS	87/102 (85)
Chloramphenicol	NA	NA	12/18	6/6	18/24 (75)	9/9	NA	9/9 (100)	NS	27/33 (82)
Ceftriaxone	4/5	NA	NA	4/8	8/13 (62)	NA	3/6	3/6 (50)	NS	11/19 (58)
Cotrimoxazole	2/7	15/24	17/38	1/7	35/76 (46)	9/9	6/6	15/15 (100)	<0.0001^‡	50/91 (55)
Tetracycline	0/8	6/18	15/22	2/5	23/53 (43)	9/9	0/1	9/10 (90)	0.0127	32/63 (51)
Amox-Clav	NA	5/5	12/33	0/4	17/42 (40)	NA	3/6	3/6 (50)	NS	20/48 (42)
Cefotaxime	NA	NA	13/32	1/2	14/34 (41)	NA	NA	NA	NA	14/34 (41)
Ampicillin	NA	3/18	7/41	0/5	10/64 (16)	0/9	NA	0/9 (0)	NS	10/73 (14)
Clindamycin	1/10	NA	6/33	0/2	7/45 (16)	0/9	NA	0/9 (0)	NS	7/54 (13)
Cephalothin	0/4	2/20	NA	0/3	2/27 (7)	2/9	NA	2/9 (22)	NS	4/36 (11)
Penicillin	0/4	1/23	2/40	0/7	3/74 (4)	0/9	1/3	1/12 (8)	NS	4/86 (5)
Oxacillin	0/8	0/15	NA	0/7	0/30 (0)	0/9	NA	0/9 (0)	NS	0/39 (0)

NA: not applicable; NS: not significant.
^†Number of clinical isolates susceptible to the antibiotic/total number of clinical isolates tested.
^‡Comparison of the antibiotic susceptibility between Europe and the US, corrected .
Comparison of the antibiotic susceptibility between Europe and the US, corrected .