Comparative Evaluation of Anthelmintic Activity of Edible and Ornamental Pomegranate Ethanolic Extracts against Schistosoma mansoni

Table 2

Effect of oral administration of different doses of SEP, LEP, LOP, and SOP extracts in vivo.

Group	Dose; (mg/kg)	Granuloma number		Granuloma diameter (GD)		Eggs in liver tissue	Immunohistochemical findings
		Mean SE	Reduction%	Mean (μm) SE	Reduction%		iNos hepatocytes	iNos inflammatory cells
SEP; (G5&G7)	600	51.2	57.8	141.2 22.1	40.1	Absent	Weakest	Negative
	800	45.3	62.7	139.2 24.5	40.9	Absent	Weakest	Negative
LEP; (G4&G6)	600	59.1	51.3	154.3 11.2	34.5	Numerous	Strong	Strong
	800	55.7	54.1	148.1 22.1	37.2	Absent	Weak	Weak
LOP; (G8&G10)	600	63.2	47.9	168.1 22.1	28.7	Numerous	Strong	Strong
	800	60.8	49.9	164.5 21.2	30.2	Few	Weak	Strong
SOP; (9&G11)	600	68.2	43.8	189.4 24.5	19.6	Numerous	Strong	Strong
	800	57.3	52.8	176.2 25.1	25.2	Few	Strong	Strong
PZQ(G3)	200	39.4	67.6	135.4 20.3	42.5	Absent	Weakest	Negative
Infected untreated controls (G1&G2)		121.3	—	235.7 16.1	—	Numerous	Strong	Strong

The difference was significant at and compared to infected untreated control group.