Review Article
Decreased Cytotoxicity of Peripheral and Peritoneal Natural Killer Cell in Endometriosis
Table 1
Change of the immunoregulatory factors in the NK cell cytotoxicity.
| Decreased cytotoxic activity | Increased inhibitory activity |
| Cytotoxic function | Inflammatory cytokines | Granzyme B, perforin, TRAIL, CD107a | IL-6, IL-8, IL-1b, IFN-γ, TNF-α | Cell-activating receptors | Noninflammatory cytokines | NKp46, NKp44, NKG2D, CD16 (cell surface marker) | CXCL8, CCL-2 (MCP-1), CCL5 (RANTES) | CD69 (markers of activation) | Antigen | | HLA-G, HLA-E, HLA-I | | Inhibitory receptors | | ITIM-KIRs, KIR2DL1, NKB1, EB6, I-CAM | | Apoptosis | | FasL (CD95) |
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