Associations of Genetic Variants at Nongenic Susceptibility Loci with Breast Cancer Risk and Heterogeneity by Tumor Subtype in Southern Han Chinese Women
Table 2
Association between four nongenic polymorphisms and breast cancer risk.
SNP or model
Genotype or allele
Controls (%) ()
Cases (%) ()
Raw OR (95% CI)
Raw
Adjusted OR (95% CI)
Adjusted
rs13387042
Codominant model
G/G
704 (82.5%)
472 (77.9%)
Reference
Reference
G/A
145 (17.0%)
128 (21.1%)
1.32 (1.01–1.72)
0.04
1.27 (0.97–1.67)
0.08
A/A
4 (0.5%)
6 (1.0%)
2.24 (0.63–7.97)
0.21
1.96 (0.54–7.13)
0.31
Dominant model
G/A + A/A
149 (17.5%)
134 (22.1%)
1.34 (1.03–1.74)
0.03
1.29 (0.99–1.69)
0.06
Recessive model
G/G + G/A
849 (99.5%)
600 (99.0%)
Reference
Reference
A/A
4 (0.5%)
6 (1.0%)
2.12 (0.60–7.55)
0.24
1.87 (0.52–6.80)
0.33
Overdominant model
G/G + A/A
708 (83.0%)
478 (78.9%)
Reference
Reference
G/A
145 (17.0%)
128 (21.1%)
1.31 (1.00–1.70)
0.048
1.27 (0.97–1.66)
0.08
Log-additive model
G
1553 (91.0%)
1072 (88.4%)
Reference
Reference
A
153 (9.0%)
140 (11.6%)
1.34 (1.05–1.72)
0.02
1.29 (1.00–1.66)
0.046
rs981782
Codominant model
T/T
360 (41.0%)
252 (41.4%)
Reference
Reference
G/T
392 (44.6%)
260 (42.7%)
0.95 (0.76–1.19)
0.64
0.96 (0.76–1.20)
0.71
G/G
127 (14.4%)
97 (15.9%)
1.09 (0.80–1.49)
0.58
1.08 (0.79–1.48)
0.61
Dominant model
G/T + G/G
519 (59.0%)
357 (58.6%)
0.98 (0.80–1.21)
0.87
0.99 (0.80–1.22)
0.92
Recessive model
T/T + G/T
752 (85.5%)
512 (84.1%)
Reference
Reference
G/G
127 (14.4%)
97 (15.9%)
1.12 (0.84–1.49)
0.43
1.11 (0.83–1.48)
0.49
Overdominant model
T/T + G/G
487 (55.4%)
349 (57.3%)
Reference
Reference
G/T
392 (44.6%)
260 (42.7%)
0.93 (0.75–1.14)
0.47
0.94 (0.76–1.16)
0.55
Log-additive model
T
1112 (63.3%)
764 (62.7%)
Reference
Reference
G
646 (36.7%)
454 (37.3%)
1.02 (0.88–1.18)
0.78
1.02 (0.88–1.19)
0.78
rs4415084
Codominant model
T/T
244 (28.4%)
208 (34.3%)
Reference
Reference
C/T
453 (52.8%)
300 (49.5%)
0.78 (0.61–0.98)
0.04
0.77 (0.60–0.98)
0.03
C/C
161 (18.8%)
98 (16.2%)
0.71 (0.52–0.98)
0.03
0.70 (0.51–0.96)
0.03
Dominant model
C/T + C/C
614 (71.6%)
398 (65.7%)
0.76 (0.61–0.95)
0.02
0.75 (0.60–0.94)
0.01
Recessive model
T/T + C/T
697 (81.2%)
508 (83.8%)
Reference
Reference
C/C
161 (18.8%)
98 (16.2%)
0.84 (0.63–1.10)
0.20
0.83 (0.63–1.10)
0.19
Overdominant model
T/T + C/C
405 (47.2%)
306 (50.5%)
Reference
Reference
C/T
453 (52.8%)
300 (49.5%)
0.88 (0.71–1.08)
0.21
0.87 (0.71–1.08)
0.20
Log-additive model
T
941 (54.8%)
716 (59.1%)
Reference
Reference
C
775 (45.2%)
496 (40.9%)
0.83 (0.72–0.97)
0.02
0.83 (0.71–0.97)
0.01
rs1562430
Codominant model
A/A
594 (67.6%)
415 (68.1%)
Reference
Reference
G/A
254 (28.9%)
165 (27.1%)
0.93 (0.74–1.17)
0.54
0.95 (0.75–1.20)
0.65
G/G
31 (3.5%)
29 (4.8%)
1.34 (0.79–2.26)
0.27
1.20 (0.71–2.04)
0.50
Dominant model
G/A + G/G
285 (32.4%)
194 (31.9%)
0.97 (0.78–1.22)
0.82
0.98 (0.78–1.22)
0.83
Recessive model
A/A + G/A
848 (96.5%)
580 (95.2%)
Reference
Reference
G/G
31 (3.5%)
29 (4.8%)
1.37 (0.82–2.29)
0.24
1.22 (0.72–2.06)
0.46
Overdominant model
A/A + G/G
625 (71.1%)
444 (72.9%)
Reference
Reference
G/A
254 (28.9%)
165 (27.1%)
0.91 (0.73–1.15)
0.45
0.94 (0.74–1.18)
0.58
Log-additive model
A
1442 (82.0%)
995 (81.7%)
Reference
Reference
G
316 (18.0%)
223 (18.3%)
1.02 (0.85–1.23)
0.82
1.01 (0.84–1.22)
0.93
Adjusted for age, age at first full-term pregnancy, menopausal status, and hormonal therapy status. OR, odds ratio; CI, confidence interval.
