Associations of Genetic Variants at Nongenic Susceptibility Loci with Breast Cancer Risk and Heterogeneity by Tumor Subtype in Southern Han Chinese Women
Table 3
Association between four nongenic polymorphisms and Luminal-A breast cancer risk.
SNP or model
Genotype or allele
Controls (%) ()
Cases (%) ()
Raw OR (95% CI)
Raw
Adjusted OR (95% CI)
Adjusted
rs13387042
Codominant model
G/G
704 (82.5%)
202 (77.7%)
Reference
Reference
G/A
145 (17%)
52 (20.0%)
1.25 (0.88–1.78)
0.22
1.20 (0.84–1.71)
0.32
A/A
4 (0.5%)
6 (2.3%)
5.23 (1.46–18.70)
0.01
4.67 (1.29–16.91)
0.02
Dominant model
G/A + A/A
149 (17.5%)
58 (22.3%)
1.36 (0.96–1.91)
0.08
1.29 (0.92–1.83)
0.15
Recessive model
G/G + G/A
849 (99.5%)
254 (97.7%)
Reference
Reference
A/A
4 (0.5%)
6 (2.3%)
5.01 (1.40–17.91)
0.01
4.51 (1.25–16.30)
0.02
Overdominant model
G/G + A/A
708 (83.0%)
208 (80.0%)
Reference
Reference
G/A
145 (17.0%)
52 (20.0%)
1.22 (0.86–1.74)
0.27
1.17 (0.82–1.67)
0.39
Log-additive model
G
1553 (91.0%)
456 (87.7%)
Reference
Reference
A
153 (9.0%)
64 (12.3%)
1.43 (1.05–1.95)
0.03
1.36 (1.00–1.87)
0.05
rs981782
Codominant model
T/T
360 (41.0%)
108 (41.1%)
Reference
Reference
G/T
392 (44.6%)
108 (41.1%)
0.92 (0.68–1.24)
0.58
0.93 (0.68–1.26)
0.62
G/G
127 (14.4%)
47 (17.8%)
1.23 (0.83–1.84)
0.30
1.24 (0.83–1.85)
0.29
Dominant model
G/T + G/G
519 (59.0%)
155 (58.9%)
1.00 (0.75–1.32)
0.97
1.00 (0.76–1.33)
0.98
Recessive model
T/T + G/T
752 (85.5%)
216 (82.1%)
Reference
Reference
G/G
127 (14.4%)
47 (17.9%)
1.29 (0.89–1.86)
0.18
1.29 (0.89–1.87)
0.18
Overdominant model
T/T + G/G
487 (55.4%)
155 (58.9%)
Reference
Reference
G/T
392 (44.6%)
108 (41.1%)
0.87 (0.65–1.14)
0.31
0.87 (0.66–1.16)
0.34
Log-additive model
T
1112 (63.3%)
324 (61.6%)
Reference
Reference
G
646 (36.7%)
202 (38.4%)
1.07 (0.88–1.30)
0.50
1.07 (0.88–1.31)
0.48
rs4415084
Codominant model
T/T
244 (28.4%)
87 (33.5%)
Reference
Reference
C/T
453 (52.8%)
134 (51.5%)
0.83 (0.61–1.13)
0.24
0.82 (0.60–1.12)
0.22
C/C
161 (18.8%)
39 (15.0%)
0.68 (0.44–1.04)
0.08
0.67 (0.44–1.03)
0.07
Dominant model
C/T + C/C
614 (71.6%)
173 (66.5%)
0.79 (0.59–1.06)
0.12
0.78 (0.58–1.05)
0.11
Recessive model
T/T + C/T
697 (81.2%)
221 (85.0%)
Reference
Reference
C/C
161 (18.8%)
39 (15.0%)
0.76 (0.52–1.12)
0.16
0.76 (0.52–1.11)
0.15
Overdominant model
T/T + C/C
405 (47.2%)
126 (48.5%)
Reference
Reference
C/T
453 (52.8%)
134 (51.5%)
0.95 (0.72–1.26)
0.72
0.94 (0.71–1.25)
0.69
Log-additive model
T
941 (54.8%)
308 (59.8%)
Reference
Reference
C
775 (45.2%)
212 (40.8%)
0.83 (0.67–1.01)
0.08
0.82 (0.66–1.00)
0.048
rs1562430
Codominant model
A/A
594 (67.6%)
177 (67.3%)
Reference
Reference
G/A
254 (28.9%)
71 (27.0%)
0.94 (0.69–1.28)
0.69
0.96 (0.70–1.32)
0.80
G/G
31 (3.5%)
15 (5.7%)
1.62 (0.86–3.08)
0.14
1.49 (0.78–2.83)
0.23
Dominant model
G/A + G/G
285 (32.4%)
86 (32.7%)
1.01 (0.75–1.36)
0.93
1.02 (0.76–1.37)
0.88
Recessive model
A/A + G/A
848 (96.5%)
248 (94.3%)
Reference
Reference
G/G
31 (3.5%)
15 (5.7%)
1.65 (0.88–3.11)
0.13
1.50 (0.79–2.85)
0.22
Overdominant model
A/A + G/G
625 (71.1%)
192 (73.0%)
Reference
Reference
G/A
254 (28.9%)
71 (27.0%)
0.91 (0.67–1.24)
0.55
0.94 (0.69–1.28)
0.68
Log-additive model
A
1442 (82.0%)
425 (80.8%)
Reference
Reference
G
316 (18.0%)
101 (19.2%)
1.08 (0.85–1.38)
0.53
1.07 (0.84–1.37)
0.57
Adjusted for age, age at first full-term pregnancy, menopausal status, and hormonal therapy status. OR, odds ratio; CI, confidence interval.
