Transcriptional Regulation of lncRNA Genes by Histone Modification in Alzheimer’s Disease

Figure 3

A lncRNA gene named Gm20559 with differential H3K4me3 modification level in the promoter between AD and control samples shows differential expression in exon 1 and exon 3. The red rectangle shows exon 1 and exon 3 regions of differentially expressed lncRNA gene Gm20559. And the green rectangle shows differential H3K4me3 histone modification in the promoter region, which suggests transcriptional regulation of Gm20559 by H3K4me3.