Phytochemical Screening and Antinociceptive and Antidiarrheal Activities of Hydromethanol and Petroleum Benzene Extract of Microcos paniculata Barks

Table 4

Effect of standard, HMPB, and PBMPB in tail immersion test.

Group	Dose	Latency time (s)
		0 min	+30 min	+60 min	+120 min	+180 min
Control	10 mL/kg	1.40 ± 0.24	2.60 ± 0.24	2.20 ± 0.20	1.60 ± 0.24	1.40 ± 0.24
Tramadol	10 mg/kg	2.20 ± 0.37	4.40 ± 0.24	5.80 ± 0.20	4.40 ± 0.24	2.60 ± 0.24
HMPB	200 mg/kg	1.80 ± 0.20	2.80 ± 0.20	1.80 ± 0.20	1.60 ± 0.24	1.20 ± 0.20
HMPB	400 mg/kg	2.80 ± 0.20	2.20 ± 0.20	2.40 ± 0.24	1.80 ± 0.20	1.60 ± 0.24
PBMPB	200 mg/kg	4.80 ± 0.20	5.40 ± 0.24	2.40 ± 0.24	3.20 ± 0.20	2.60 ± 0.24
PBMPB	400 mg/kg	5.40 ± 0.24	6.60 ± 0.31	3.20 ± 0.20	4.20 ± 0.20	3.60 ± .024

Latency time values are presented as mean ± standard error. mice in each group. 0 min means 30 min before drug administration and +30 min, +60 min, +120 min, and +180 min indicate 30, 60, 120, and 180 min after drug administration, respectively. ⁢, versus control (Dunnett’s -test); , versus tramadol 10 mg/kg; , versus HMPB 200 mg/kg; , versus HMPB 400 mg/kg; , versus PBMPB 200 mg/kg; , versus PBMPB 400 mg/kg (pairwise comparison by post hoc Tukey’s HSD test).
Tests of within-subjects effects conducted by repeated measure analysis of variance reveal that for the factor “time” calculated for all methods and value = 0.000 in every case. So time is highly significant at any level of significance.