Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2016 (2016), Article ID 3185397, 9 pages
http://dx.doi.org/10.1155/2016/3185397
Research Article

The NLRP3 rs10754558 Polymorphism Is Associated with the Occurrence and Prognosis of Coronary Artery Disease in the Chinese Han Population

1Department of Cardiovascular Medicine, First Affiliated Hospital of Medical School, Xi’an Jiaotong University, 277 Yanta West Road, Xi’an, Shaanxi 710061, China
2Department of Cardiovascular Medicine, 3201 Hospital, 783 Tianhan Road, Hanzhong, Shaanxi 723000, China
3Department of Cardiovascular Medicine, Second Affiliated Hospital of Medical School, Xi’an Jiaotong University, 157 West Five Road, Xi’an, Shaanxi 710004, China
4Key Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, Shaanxi 710061, China

Received 8 November 2015; Accepted 14 January 2016

Academic Editor: Fabrizio Montecucco

Copyright © 2016 Dong Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The objective of this study is to investigate the potential association of the NLRP3 rs10754558 and CARD8 rs2043211 polymorphisms with the occurrence and prognosis of CAD. Gene polymorphisms were analyzed using the ABI PRISM-Snapshot multiplex method in 515 CAD patients and 401 control subjects. The serum level of IL-1β was investigated by ELISA assays. The clinical endpoints were evaluated during a median follow-up period of 32 months. The NLRP3 rs10754558 gene polymorphism was significantly associated with the occurrence of CAD, while the CARD8 rs2043211 gene polymorphism was not involved. Patients carrying G allele of NLRP3 rs10754558 had more severe coronary artery stenosis. Multivariable analysis revealed a significant association of the G allele with major adverse cardiac event. The serum IL-1β concentrations in patients with GG genotype were significantly increased compared with those in the patients with CC genotype. Our findings for the first time show that the NLRP3 rs10754558 polymorphism is involved in the occurrence of CAD in the Chinese Han population; and G allele can effectively predict clinical outcome of CAD. The G allele susceptibility to CAD is maybe associated with the increased level of serum IL-1β.