The NLRP3 rs10754558 Polymorphism Is Associated with the Occurrence and Prognosis of Coronary Artery Disease in the Chinese Han Population
Table 2
Genotype frequencies of NLRP3 rs10754558 and CARD8 rs2043211 in the control and CAD subjects.
Control
CAD
AOR (95% CI)
P
()
()
NLRP3 rs10754558
CC
142 (35.41%)
149 (28.93%)
1.000 (reference)
CG
200 (49.88%)
263 (51.07%)
1.294 (0.952–1.758)
0.099
GG
59 (14.71%)
103 (20.00)
1.630 (1.080–2.459)
0.020
Dominant model (CC versus CG + GG)
1.371 (1.024–1.835)
0.034
Recessive model (CC + CG versus GG)
1.392 (0.965–2.007)
0.077
C allele
484 (60.35%)
561 (54.47%)
1.000 (reference)
G allele
318 (39.65%)
469 (45.53%)
1.263 (1.041–1.534)
0.018
HWE
0.713
0.450
HWE
0.399
0.502
CARD8 rs2043211
AA
175 (43.64%)
210 (40.78%)
1.000 (reference)
AT
186 (46.38%)
244 (47.38%)
1.160 (0.870–1.545)
0.311
TT
40 (9.98%)
61 (11.84%)
1.252 (0.787–1.990)
0.343
Dominant model (AA versus AT + TT)
1.176 (0.894–1.547)
0.245
Recessive model (AA + AT versus TT)
1.158 (0.747–1.795)
0.513
A allele
536 (66.83%)
664 (64.47%)
1.000 (reference)
T allele
266 (33.17%)
366 (35.53%)
1.126 (0.921–1.377)
0.248
HWE
0.858
0.600
HWE
0.354
0.439
CAD: coronary artery disease; AOR: adjusted odds ratio; HWE: Hardy-Weinberg equilibrium; 95% CI: 95% confidence interval. The AOR on the basis of risk factors such as age, sex, hypertension, diabetes mellitus, hyperlipidemia, and smoking.
