The NLRP3 rs10754558 Polymorphism Is Associated with the Occurrence and Prognosis of Coronary Artery Disease in the Chinese Han Population
Table 4
Genotype frequencies of NLRP3 rs10754558 and CARD8 rs2043211 gene polymorphisms in CAD patients with and without MACE during follow-up.
Patients without MACE
Patients with MACE
Adjusted HR (95% CI)
Log-rank P
()
()
NLRP3 rs10754558
CC
113 (31.56%)
32 (22.07%)
1.000 (reference)
CG
180 (50.28%)
75 (51.72%)
1.503 (0.990–2.282)
0.056
GG
65 (18.16%)
38 (26.21%)
1.790 (1.107–2.893)
0.017
Dominant model (CC versus CG + GG)
1.585 (1.065–2.359)
0.023
Recessive model (CC + CG versus GG)
1.363 (0.934–1.989)
0.108
C allele
406 (56.70%)
139 (47.93%)
1.000 (reference)
G allele
310 (43.30%)
151 (52.07%)
1.502 (1.182–1.909)
0.001
HWE
0.206
0.191
HWE P
0.650
0.662
CARD8 rs2043211
AA
146 (40.78%)
60 (41.38%)
1.000 (reference)
AT
168 (46.93%)
68 (46.90%)
1.193 (0.831–1.711)
0.338
TT
44 (12.29%)
17 (11.72%)
0.850 (0.483–1.497)
0.574
Dominant model (AA versus AT + TT)
1.111 (0.786–1.571)
0.551
Recessive model (AA + AT versus TT)
1.044 (0.981–1.111)
0.174
A allele
460 (64.25%)
188 (64.83%)
1.000 (reference)
T allele
256 (35.75%)
102 (35.17%)
0.992 (0.774–1.272)
0.949
HWE
0.165
0.117
HWE
0.685
0.733
CAD: coronary artery disease; HR: hazard risk; MACE: major adverse cardiovascular event. HWE: Hardy-Weinberg equilibrium; 95% CI: 95% confidence interval. The adjusted HR on the basis of risk factors such as age, sex, hypertension, diabetes mellitus, hyperlipidemia, and smoking.
