Treating Diabetes Mellitus: Pharmacophore Based Designing of Potential Drugs from Gymnema sylvestre against Insulin Receptor Protein

Figure 7

Interaction between drugs (a–f) and active site amino acid residues of 3LOH_E. (a) Conduritol E tetranitro, (b) GS4, (c) Gymnemic acid I, (d) Gymnemic acid II, (e) Gymnemoside A, and (f) Gymnemoside B. Red stick represents the drug compounds. Yellow dots represent the hydrogen bond interaction. Red dots represent the electrostatic interactions and blue dot also represents the hydrophobic interactions with amino acid residues. The common interactions with amino acid residues among the six compounds are Val 377, Glu 438, and Leu 472.

(a)

(b)

(c)

(d)

(e)

(f)