Treating Diabetes Mellitus: Pharmacophore Based Designing of Potential Drugs from Gymnema sylvestre against Insulin Receptor Protein

Figure 8

Interaction between the four novel designed molecules and active site amino acid residues of 3LOH_E. (a) Space filling model of 3LOH_E with four novel designed molecules in the active site cleft of E chain. (b) Designed drug compounds interactions with amino acid residues of insulin receptor chain E. (A) Conduritol A analogue, (B) Conduritol B tetraacetate analogue, (C) Conduritol C cis-epoxide analogue, and (D) Conduritol D analogue. Here, marine sticks designate the drug compounds. The interactions with most common amino acid residues of these novel molecules are Val 377, Lys 433, Cys 435, Glu 438, and Ala 466.

(a)

(b)