iTRAQ-Based Proteomics Identification of Serum Biomarkers of Two Chronic Hepatitis B Subtypes Diagnosed by Traditional Chinese Medicine

Table 2

Commonly up- and downregulated proteins in LSSD-CHB and SSDHS-CHB groups (part).

Family	UniProt_ID	Gene_name	Description	Number of significant matches	Number of significant sequences	emPAI	LSSD-CHB versus HCTL		SSDHS-CHB versus HCTL
							Immunoglobulin related proteins	A0A087WV47_HUMAN	IGHG1	Ig gamma-1 chain C region	1541	14	5.37	1.84		1.47
A0A087WYC5_HUMAN	IGHG1	Ig gamma-1 chain C region	1501	14	4.82	1.87			1.48
A0A087X1C7_HUMAN	IGHG1	Ig gamma-1 chain C region	1511	13	4.79	1.84			1.47
A0A087WXL8_HUMAN	IGHG3	Ig gamma-3 chain C region	739	11	2.07	1.84			1.47
A0A0G2JPD4_HUMAN	IGHG4	Ig gamma-4 chain C region (fragment)	31	6	1.56	1.69			1.24
KV112_HUMAN		Ig kappa chain V-I region Kue	2	2	0.53	1.82			1.51
KV311_HUMAN		Ig kappa chain V-III region IARC/BL41	2	1	0.49	1.61			1.28
LV302_HUMAN		Ig lambda chain V-III region LOI	25	3	4.01	1.73			1.35
LV301_HUMAN		Ig lambda chain V-III region SH	6	1	0.61	1.99			1.56
S6B2B6_HUMAN		IgG H chain	384	3	0.6	2.05			1.57
S6BAM6_HUMAN		IgG H chain	389	4	0.9	2.05			1.56
S6BGE0_HUMAN		IgG H chain	394	4	1.13	2.04			1.56
S6C4S4_HUMAN		IgG H chain	384	3	0.73	2.05			1.57
S6C4R7_HUMAN		IgG L chain	257	6	6.68	1.53			1.27
Q6GMX6_HUMAN	IGH@	IGH@ protein	1524	14	6.04	1.83			1.46
A0A0F7TC28_HUMAN	IGHV4-4	IGHV4-4 protein (fragment)	3	2	1.27	1.49			1.24
Q5FWF9_HUMAN	IGL@	IGL@ protein	143	6	6.03	1.60			1.32
Q6PIK1_HUMAN	IGL@	IGL@ protein	197	5	4.45	1.59			1.29
Q9UL84_HUMAN		Myosin-reactive immunoglobulin heavy chain variable region (fragment)	6	3	1.69	1.52			1.46
Q9UL79_HUMAN		Myosin-reactive immunoglobulin light chain variable region (fragment)	2	1	0.57	0.65			0.50
A0A0C4DH33_HUMAN	IGHV1-24	Protein IGHV1-24 (fragment)	5	2	0.84	0.82			0.81
A0A0A0MT74_HUMAN	IGKV1-16	Protein IGKV1-16 (fragment)	5	1	0.9	1.58			1.26
A0A075B6I9_HUMAN	IGLV7-46	Protein IGLV7-46 (fragment)	31	3	1.41	1.54			1.36
Complement	B7Z1F8_HUMAN		cDNA FLJ53025, highly similar to complement C4-B	2230	12	56.68	0.78		0.77
	B4E3S6_HUMAN		cDNA FLJ58413, highly similar to complement component C7	63	10	1.74	0.55		0.50
	A8K2T4_HUMAN		cDNA FLJ78207, highly similar to human complement protein component C7 mRNA	86	15	1.31	0.55		0.50
	B2RA39_HUMAN		cDNA, FLJ94686, highly similar to Homo sapiens complement factor H-related 5 (CFHL5), mRNA	35	5	0.51	0.54		0.57
	CO4A_HUMAN	C4A	Complement C4-A	5889	65	21.28	0.79		0.75
	CO4B_HUMAN	C4B	Complement C4-B	5983	66	23.03	0.79		0.74
	A0A024R035_HUMAN	C9	Complement component 9, isoform CRA_a	225	17	5.12	0.67		0.54
	CO6_HUMAN	C6	Complement component C6	92	12	0.83	0.50		0.48
	CO8A_HUMAN	C8A	Complement component C8 alpha chain	66	8	1.51	0.66		0.53
	F5GY80_HUMAN	C8B	Complement component C8 beta chain	133	16	3.28	0.65		0.61
	CO8G_HUMAN	C8G	Complement component C8 gamma chain	41	8	6.86	0.61		0.50
	B1AKG0_HUMAN	CFHR1	Complement factor H-related protein 1	216	6	4.26	0.66		0.75
	FHR3_HUMAN	CFHR3	Complement factor H-related protein 3	45	6	1.19	0.82		0.77
	FHR4_HUMAN	CFHR4	Complement factor H-related protein 4	31	3	0.41	0.37		0.31
	A0A0S2Z4I5_HUMAN	CFP	Complement factor properdin isoform 1 (fragment)	13	2	0.17	0.58		0.72
Apolipoprotein	APOA2_HUMAN	APOA2	Apolipoprotein A-II	421	2	1.84	1.48		1.26
	A0A0B4RUS7_HUMAN	APOA5	Apolipoprotein A-V, isoform CRA_a	15	7	1	0.73		0.62
	E1B4S9_HUMAN	APOB	Apolipoprotein B (fragment)	129	7	10.94	1.97		1.53
	C0JYY2_HUMAN	APOB	Apolipoprotein B (including Ag(X) antigen)	5227	215	21.89	1.84		1.44
	Q59HB3_HUMAN		Apolipoprotein B variant (fragment)	1661	69	16.33	1.85		1.41
	B0YIW2_HUMAN	APOC3	Apolipoprotein C-III	577	5	8.48	0.66		0.55
	APOC4_HUMAN	APOC4	Apolipoprotein C-IV	26	5	3.84	0.80		0.60
Histone	H15_HUMAN	HIST1H1B	Histone H1.5	4	2	0.35	2.02		1.72
	A0A024R017_HUMAN	HIST1H2AC	Histone H2A	21	4	2.27	4.67		3.63
	C9J0D1_HUMAN	H2AFV	Histone H2A	13	3	1.11	4.84		3.73
	A0A024QZZ7_HUMAN	HIST1H2BD	Histone H2B	12	4	1.15	4.58		3.38
	B2R4P9_HUMAN	H3F3A	Histone H3	9	3	0.88	4.98		3.72
	Q5TEC6_HUMAN	HIST2H3PS2	Histone H3	4	3	0.6	2.59		1.87
	B2R4R0_HUMAN	HIST1H4J	Histone H4	39	5	13.27	4.47		3.41
Heat shock protein	A0A024RD80_HUMAN	HSP90AB1	Heat shock protein 90 kDa alpha (cytosolic), class B member 1, isoform CRA_a	12	6	0.31	1.46		1.51
	HS90A_HUMAN	HSP90AA1	Heat shock protein HSP 90-alpha	28	10	0.55	1.58		1.65
Insulin-like growth factor binding protein	C1K3N3_HUMAN	IGFBP1	Insulin-like growth factor binding protein 1 (fragment)	3	2	0.22	0.61		0.60
	A0A024R1U8_HUMAN	IGFBP4	Insulin-like growth factor binding protein 4, isoform CRA_a	2	1	0.1	0.66		0.66
	A0A024R433_HUMAN	IGFBP5	Insulin-like growth factor binding protein 5, isoform CRA_a	3	2	0.18	0.83		0.80
Ras-related protein	A0A024R7I3_HUMAN	RAB8A	RAB8A, member RAS oncogene family, isoform CRA_a	11	4	1.08	1.75		1.73
	A0A024RB87_HUMAN	RAP1B	RAP1B, member of RAS oncogene family, isoform CRA_a	10	4	1.66	1.85		1.96
	RAB10_HUMAN	RAB10	Ras-related protein Rab-10	9	3	0.71	1.74		1.72
	RB11B_HUMAN	RAB11B	Ras-related protein Rab-11B	5	4	0.73	1.91		1.57
	RAB1B_HUMAN	RAB1B	Ras-related protein Rab-1B	12	6	1.5	1.73		1.73
	RB27B_HUMAN	RAB27B	Ras-related protein Rab-27B	5	4	0.7	1.70		1.59
	RAB7A_HUMAN	RAB7A	Ras-related protein Rab-7a	16	6	1.94	1.60		1.66
Serum amyloid	D3DQX7_HUMAN	SAA1	Serum amyloid A protein	59	5	9.88	0.53		0.40
	SAA1_HUMAN	SAA1	Serum amyloid A-1 protein	40	4	4.99	0.48		0.38
	SAA2_HUMAN	SAA2	Serum amyloid A-2 protein	24	4	4.99	0.48		0.36
	SAMP_HUMAN	APCS	Serum amyloid P-component	228	8	15.23	0.83		0.70
von Willebrand factor	L8E853_HUMAN	VWF	von Willebrand factor	189	38	0.98	1.68		1.41
	VWF_HUMAN	VWF	von Willebrand factor	186	38	0.93	1.67		1.41

change provided by MASCOT.
values calculated by edgeR to show the significance of different expression.