Complement Factor 3 Could Be an Independent Risk Factor for Mortality in Patients with HBV Related Acute-on-Chronic Liver Failure

Table 2

Factors associated with mortality in univariate Cox regression analysis.

Variables	value	Hazard ratio	95% CI
Age (years)	0.032	1.029	1.002–1.057
HBeAg-positive	0.190	1.538	0.807–2.931
MELD-Na	<0.001	1.206	1.100–1.322
Tbil (mg/dL)	0.490	1.009	0.984–1.034
PTA (%)	<0.001	0.919	0.880–0.959
AST (U/L)	0.019	1.001	1.000–1.001
ALT (U/L)	0.242	1.000	1.000–1.001
ALB (g/L)	0.631	1.014	0.958–1.074
GLB (g/L)	0.912	1.002	0.964–1.042
Creatinine (mol/L)	0.002	1.017	1.006–1.028
AFP (ng/mL)	0.753	1.000	0.998–1.001
DNA (log10IU/mL)	0.061	1.004	1.000–1.009
C3 (g/L)	0.001
0.16 ≤ C3 < 0.3	<0.001	4.625	2.018–10.600
0.3 ≤ C3 < 0.45	0.007	3.483	1.402–8.653
C4 (g/L)	0.816	2.566	0.001–7060.782
CH50 (U/mL)	0.742	0.994	0.960–1.030
Antiviral therapy	0.085	1.811	0.921–3.557

AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALB, albumin; GLB, globulin; and AFP, alpha-fetoprotein.