Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation

Table 3

Number and frequency (%) of levels of biochemically and histologically confirmed renal injury among subjects and comparisons between control versus EPO and ROSC versus non-ROSC subjects.

Parameter	Total	Group C	Group E	value
ROSC	16 (66.67)	5 (41.67)	11 (91.67)	0.027
Renal injury (ROSC subjects)
None	3 (18.75)	0 (0.00)	3 (27.27)	<0.001
Mild	3 (18.75)	0 (0.00)	3 (27.27)
Moderate	5 (31.25)	0 (0.00)	5 (45.45)
Severe	0 (0.00)	0 (0.00)	0 (0.00)
AKI	5 (31.25)	5 (100.00)	0 (0.00)
AKI (ROSC subjects)	5 (31.25)	5 (100.00)	0 (0.00)	<0.001
Severe injury or AKI (ROSC subjects)	5 (31.25)	5 (100.00)	0 (0.00)	<0.001

ROSC = return of spontaneous circulation; AKI = acute kidney injury.
0.01 < value ≤ 0.05; value ≤ 0.001, for differences in AKI frequencies of ROSC versus non-ROSC subjects (within either total of subjects or same treatment group, accordingly); differences marked with asterisks next to “none”; kidney damage category frequencies correspond to overall frequency differences for all kidney damage categories (i.e., not only specific differences for “none”).