Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation
Table 6
Biochemical markers and effect of hemodynamic measurements (per unit increase) for ROSC subjects ().
Parameter
Effect of hemodynamic measurement on biochemical marker
value
-coefficient (95% C.I.)
Creatinine (mg/dL)
CPR: SAoP (per mmHg)
−0.004 (−0.030 to 0.023)
0.780
CPR: DAoP (per mmHg)
−0.016 (−0.032 to 0.001)
0.070
CPR: MAoP (per mmHg)
−0.015 (−0.035 to 0.004)
0.106
CPR: CPP (per mmHg)
−0.014 (−0.029 to 0.002)
0.082
ROSC: SAoP (per mmHg)
0.029 (0.015 to 0.044)
0.001
ROSC: DAoP (per mmHg)
−0.018 (−0.060 to 0.023)
0.360
ROSC: MAoP (per mmHg)
0.023 (−0.023 to 0.069)
0.306
ROSC: CPP (per mmHg)
−0.011 (−0.048 to 0.026)
0.541
NGAL (ng/mL)
CPR: SAoP (per mmHg)
−12.730 (−19.455 to −6.006)
0.001
CPR: DAoP (per mmHg)
−8.317 (−14.341 to −2.293)
0.010
CPR: MAoP (per mmHg)
−10.293 (−17.009 to −3.577)
0.005
CPR: CPP (per mmHg)
−7.808 (−13.295 to −2.322)
0.008
ROSC: SAoP (per mmHg)
6.789 (−1.845 to 15.424)
0.114
ROSC: DAoP (per mmHg)
−20.694 (−30.126 to −11.263)
<0.001
ROSC: MAoP (per mmHg)
−3.240 (−23.362 to 16.883)
0.736
ROSC: CPP (per mmHg)
−13.899 (−22.804 to −4.994)
0.005
L-FABP (ng/mL)
CPR: SAoP (per mmHg)
−0.021 (−0.033 to −0.009)
0.002
CPR: DAoP (per mmHg)
−0.014 (−0.024 to −0.004)
0.011
CPR: MAoP (per mmHg)
−0.017 (−0.029 to −0.006)
0.006
CPR: CPP (per mmHg)
−0.013 (−0.022 to −0.004)
0.010
ROSC: SAoP (per mmHg)
0.011 (−0.004 to 0.026)
0.139
ROSC: DAoP (per mmHg)
−0.036 (−0.051 to −0.021)
<0.001
ROSC: MAoP (per mmHg)
−0.006 (−0.041 to 0.028)
0.693
ROSC: CPP (per mmHg)
−0.025 (−0.039 to −0.010)
0.002
IL-18 (ng/mL)
CPR: SAoP (per 10 mmHg)†
−0.013 (−0.021 to −0.005)
0.004
CPR: DAoP (per 10 mmHg)†
−0.010 (−0.017 to −0.003)
0.010
CPR: MAoP (per 10 mmHg)†
−0.012 (−0.020 to −0.004)
0.006
CPR: CPP (per 10 mmHg)†
−0.009 (−0.016 to −0.003)
0.010
ROSC: SAoP (per 10 mmHg)†
0.010 (−0.001 to 0.020)
0.059
ROSC: DAoP (per 10 mmHg)†
−0.023 (−0.034 to −0.012)
0.001
ROSC: MAoP (per 10 mmHg)†
−0.001 (−0.026 to 0.023)
0.910
ROSC: CPP (per 10 mmHg)†
−0.015 (−0.026 to −0.005)
0.008
Comparisons regarding overall measurements utilize clustered regression models for longitudinal data, with summed hemodynamic measurements being the dependent variables and (repeatedly measured) biochemical markers being the independent variable (i.e., effect of mean hemodynamic measurements on biochemical markers); each row corresponds to separate model regarding the effect of specific hemodynamic measurement on specific biochemical marker. Hemodynamic measurements refer to all time-points summed as mean, according to protocol period (2–8 minutes for CPR, 0–120 minutes for ROSC), apart from baseline. Effects refer to per 10 mmHg change in mean hemodynamic measurements, due to very small -coefficients.
