Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation
Table 7
Biochemical measurements and concurrent effect of hemodynamic measurements (per unit increase) and histopathological group (presence of AKI) for ROSC subjects ().
Parameter
Effect of hemodynamic measurement
value
Effect of AKI presence
value
-coefficient (95% C.I.)
-coefficient (95% C.I.)
Creatinine (mg/dL)
CPR: SAoP (per mmHg)
0.025 (−0.001 to 0.051)
0.012
0.675 (0.377 to 0.974)
<0.001
CPR: DAoP (per mmHg)
−0.001 (−0.006 to 0.005)
0.860
0.513 (0.112 to 0.913)
0.016
CPR: MAP (per mmHg)
0.005 (−0.006 to 0.015)
0.369
0.560 (0.177 to 0.944)
0.007
CPR: CPP (per mmHg)
0.001 (−0.005 to 0.007)
0.799
0.526 (0.119 to 0.933)
0.015
ROSC: SAoP (per mmHg)
0.020 (0.005 to 0.034)
0.011
0.381 (0.037 to 0.725)
0.032
ROSC: DAoP (per mmHg)
0.027 (−0.019 to 0.072)
0.228
0.641 (0.293 to 0.989)
0.001
ROSC: MAP (per mmHg)
0.027 (−0.003 to 0.058)
0.077
0.537 (0.234 to 0.840)
0.002
ROSC: CPP (per mmHg)
0.018 (−0.015 to 0.050)
0.270
0.599 (0.260 to 0.939)
0.002
NGAL (ng/mL)
CPR: SAoP (per mmHg)
−1.461 (−3.430 to 0.507)
0.134
264.050 (243.929 to 284.171)
<0.001
CPR: DAoP (per mmHg)
−0.461 (−1.568 to 0.647)
0.389
268.321 (249.770 to 286.873)
<0.001
CPR: MAP (per mmHg)
−0.739 (−2.115 to 0.637)
0.270
266.447 (246.608 to 286.285)
<0.001
CPR: CPP (per mmHg)
−0.538 (−1.612 to 0.536)
0.303
267.324 (247.535 to 287.113)
<0.001
ROSC: SAoP (per mmHg)
−0.231 (−1.077 to 0.616)
0.570
274.768 (253.272 to 296.265)
<0.001
ROSC: DAoP (per mmHg)
−2.155 (−4.935 to 0.625)
0.119
263.286 (240.501 to 286.071)
<0.001
ROSC: MAP (per mmHg)
−0.997 (−2.778 to 0.785)
0.252
272.461 (252.644 to 292.278)
<0.001
ROSC: CPP (per mmHg)
−1.180 (−3.288 to 0.929)
0.252
267.717 (248.147 to 287.287)
<0.001
L-FABP (ng/mL)
CPR: SAoP (per mmHg)
−0.001 (−0.005 to 0.002)
0.396
0.449 (0.416 to 0.481)
<0.001
CPR: DAoP (per mmHg)
−0.001 (−0.003 to 0.002)
0.573
0.450 (0.417 to 0.483)
<0.001
CPR: MAP (per mmHg)
−0.001 (−0.004 to 0.002)
0.501
0.449 (0.417 to 0.480)
<0.001
CPR: CPP (per mmHg)
−0.001 (−0.003 to 0.002)
0.676
0.452 (0.420 to 0.484)
<0.001
ROSC: SAoP (per mmHg)
−0.001 (−0.003 to 0.001)
0.380
0.464 (0.418 to 0.511)
<0.001
ROSC: DAoP (per mmHg)
−0.005 (−0.012 to 0.002)
0.141
0.434 (0.383 to 0.485)
<0.001
ROSC: MAP (per mmHg)
−0.003 (−0.007 to 0.002)
0.239
0.456 (0.414 to 0.497)
<0.001
ROSC: CPP (per mmHg)
−0.004 (−0.009 to 0.002)
0.191
0.441 (0.397 to 0.485)
<0.001
IL-18 (ng/mL)
CPR: SAoP (per 10 mmHg)†
0.001 (−0.001 to 0.004)
0.295
0.034 (0.031 to 0.038)
<0.001
CPR: DAoP (per 10 mmHg)†
−0.001 (−0.002 to 0.001)
0.407
0.033 (0.030 to 0.037)
<0.001
CPR: MAP (per 10 mmHg)†
−0.001 (−0.002 to 0.001)
0.848
0.034 (0.030 to 0.037)
<0.001
CPR: CPP (per 10 mmHg)†
−0.001 (−0.002 to 0.001)
0.805
0.034 (0.030 to 0.037)
<0.001
ROSC: SAoP (per 10 mmHg)†
0.001 (−0.001 to 0.003)
0.160
0.033 (0.030 to 0.036)
<0.001
ROSC: DAoP (per 10 mmHg)†
0.001 (−0.004 to 0.005)
0.725
0.034 (0.030 to 0.038)
<0.001
ROSC: MAP (per 10 mmHg)†
0.001 (−0.002 to 0.005)
0.399
0.034 (0.031 to 0.037)
<0.001
ROSC: CPP (per 10 mmHg)†
0.001 (−0.003 to 0.004)
0.755
0.034 (0.031 to 0.037)
<0.001
AKI presence = Group C. Comparisons regarding overall measurements utilize clustered regression models for longitudinal data, with summed hemodynamic measurements and AKI presence being the dependent variables and (repeatedly measured) biochemical markers being the independent variable (i.e., effect of mean hemodynamic measurements and AKI presence on biochemical markers); each row corresponds to model defined by separate hemodynamic measurement specified, along with presence of AKI (the two being covariates), on specific biochemical marker mentioned. Hemodynamic measurements refer to all time-points summed as mean, according to protocol period (2–8 minutes for CPR, 0–120 minutes for ROSC), apart from baseline. †Effects refer to per 10 mmHg change in mean hemodynamic measurements, due to very small -coefficients.
