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BioMed Research International
Volume 2016, Article ID 3656574, 7 pages
Clinical Study

Comprehensive Evaluation of Personal, Clinical, and Radiation Dosimetric Parameters for Acute Skin Reaction during Whole Breast Radiotherapy

1Department of Radiation Oncology, Guro Hospital, Korea University Medical Center, 148 Gurodong-ro, Guro-gu, Seoul 08308, Republic of Korea
2Department of Radiation Oncology, Ansan Hospital, Korea University Medical Center, 123 Jeokguem-ro, Ansan, Gyeonggi 15355, Republic of Korea
3Department of Radiation Oncology, Anam Hospital, Korea University Medical Center, 73 Inchon-ro, Seongbuk-gu, Seoul 02841, Republic of Korea
4Department of Surgery, Ansan Hospital, Korea University Medical Center, 123 Jeokguem-ro, Ansan, Gyeonggi 15355, Republic of Korea

Received 5 February 2016; Accepted 10 July 2016

Academic Editor: Emiliano Antiga

Copyright © 2016 Dae Sik Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Skin reaction is major problem during whole breast radiotherapy. To identify factors related to skin reactions during whole breast radiotherapy, various personal, clinical, and radiation dosimetric parameters were evaluated. From January 2012 to December 2013, a total of 125 patients who underwent breast conserving surgery and adjuvant whole breast irradiation were retrospectively reviewed. All patients had both whole breast irradiation and boost to the tumour bed. Skin reaction was measured on the first day of boost therapy based on photography of the radiation field and medical records. For each area of axilla and inferior fold, the intensity score of erythema (score 1 to 5) and extent (score 0 to 1) were summed. The relationship of various parameters to skin reaction was evaluated using chi-square and linear regression tests. The (volume receiving 100% of prescribed radiation dose, , both axilla and inferior fold) and age ( for axilla and 0.026 for inferior fold) were significant parameters in multivariate analyses. The calculated axilla dose () and breast separation () were also risk factors for axilla and inferior fold, respectively. Young age and large are significant factors for acute skin reaction that can be simply and cost-effectively measured.