Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment

Figure 1

FR901464 and derivatives. The FR9014 series were isolated from Pseudomonas sp. number 2663 and constitute the first antiproliferative molecules associated with splicing inhibition. Spliceostatin A is a methylated derivative of FR901464. Spliceostatin B was also isolated from Pseudomonas sp. number 2663. Spliceostatin E was isolated from Burkholderia sp. FERM BP3421. Thailanstatins were recovered from Burkholderia thailandensis MSMB43. Meayamycin and Sudemycins are synthetic derivatives from the natural products depicted.