Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment

Figure 4

Herboxidiene structure. The characteristic structure of GEXA1 consisting of a tetrahydrofuran with a residue of acetic acid and a conjugated diene is shown in the left. This natural product was isolated from Streptomyces sp. The derivative Trichostatin is shown at right.