Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment

Figure 6

Molecular mechanism depicted for the natural products that inhibit splicing. (a) It has been demonstrated that FR901464, Spliceostatin A, Pladienolide B, Herboxidiene, and Meayamycin have the ability to block splicing by binding SAP130, SAP145, and SAP155 subunits of snRNP U2 (green). Besides, these natural products block cell cycle in G1 and G2/M transitions (gray arrows). (b) On the other hand, Isoginkgetin blocks splicing by inhibiting the incorporation of the tri-snRNP U4/U5/U6 complex to the spliceosome.

(a)

(b)