A De-O-acylated Lipooligosaccharide-Based Adjuvant System Promotes Antibody and Th1-Type Immune Responses to H1N1 Pandemic Influenza Vaccine in Mice

Figure 5

Decrease in lung virus titers of immunized mice after viral challenge. Mice () were immunized twice with nonadjuvanted or adjuvanted Greenflu-S (0.2 μg) and challenged with influenza virus. Control mice were given PBS or CIA06. Four days after infection, lung samples were collected, and virus titers were determined by plaque assays. Statistical differences were analyzed by one-way ANOVA followed by Tukey’s multiple comparison test. Data are presented as the means ± SD of values that were obtained from each group of four mice. and . NS, not significant.