BioMed Research International / 2016 / Article / Tab 4 / Review Article
Approaches to Peripheral Nerve Repair: Generations of Biomaterial Conduits Yielding to Replacing Autologous Nerve Grafts in Craniomaxillofacial Surgery Table 4 Preclinical and experimental studies on facial nerve reconstruction by artificial nerve guidance conduits.
Study Year Conduit material Cells/factors Species Defect size or technique Regrowth time span (weeks) Outcome Cui et al. [32 ] 2014 Collagen Neurocytokines CNTF and bFGF Minipig 35 mm 24 weeks (i) Favorable mechanical properties (ii) May promote facial nerve regeneration effectively Inada et al. [33 ] 2007 Polyglycolic acid collagen blend None Human n/a 24 weeks (i) Functional and morphological regeneration Matsumine et al. [34 ] 2014 Polylactic acid, nonwoven None Rat 7 mm 13 (i) Comparable ability of autografts to induce peripheral nerve regeneration Liu et al. [35 ] 2013 Chitosan Nerve growth factor presented in microspheres Rabbit 10 mm 13 (i) Sustained release of nerve growth factor can significantly improve facial nerve defect repair Shi et al. [36 ] 2012 Polylactic-co-glycolic acid Neural stem cells (NSC) Rat Facial nerve transection 12 (i) Nerve action potential amplitude and axonal area were significantly greater in the NSC compared to an empty control group Tan et al. [37 ] 2009 Silk fibroin-chitosan blend None Rabbit 10 mm 8 (i) Successful regeneration of the facial nerve Guo and Dong [38 ] 2009 Chitosan Neural stem cells (NSC) Rabbits 10 mm 12 (i) Comparable results to an autograft in 10 mm facial nerve defects